TY  - JOUR
AU  - Galldiks, N.
AU  - Stoffels, G.
AU  - Filss, C.P.
AU  - Piroth, M.D.
AU  - Sabel, M.
AU  - Ruge, M.I.
AU  - Herzog, H.
AU  - Shah, N.J.
AU  - Fink, G.R.
AU  - Coenen, H.H.
AU  - Langen, K.J.
TI  - Role of O-(2-18 F-Fluoroethyl)-L-Tyrosine PET for differentiation of local recurrent brain metastasis from radiation necrosis
JO  - Journal of nuclear medicine
VL  - 53
IS  - 9
SN  - 0161-5505
CY  - New York, NY
PB  - Society of Nuclear Medicine
M1  - PreJuSER-22779
SP  - 1367-1374
PY  - 2012
N1  - Record converted from VDB: 12.11.2012
AB  - The aim of this study was to investigate the potential of O-(2-(18)F-fluoroethyl)-L-tyrosine ((18)F-FET) PET for differentiating local recurrent brain metastasis from radiation necrosis after radiation therapy because the use of contrast-enhanced MRI for this issue is often difficult.Thirty-one patients (mean age ± SD, 53 ± 11 y) with single or multiple contrast-enhancing brain lesions (n = 40) on MRI after radiation therapy of brain metastases were investigated with dynamic (18)F-FET PET. Maximum and mean tumor-to-brain ratios (TBR(max) and TBR(mean), respectively; 20-40 min after injection) of (18)F-FET uptake were determined. Time-activity curves were generated, and the time to peak (TTP) was calculated. Furthermore, time-activity curves of each lesion were assigned to one of the following curve patterns: (I) constantly increasing (18)F-FET uptake, (II) (18)F-FET uptake peaking early (TTP ≤ 20 min) followed by a plateau, and (III) (18)F-FET uptake peaking early (TTP ≤ 20 min) followed by a constant descent. The diagnostic accuracy of the TBR(max) and TBR(mean) of (18)F-FET uptake and the curve patterns for the correct identification of recurrent brain metastasis were evaluated by receiver-operating-characteristic analyses or Fisher exact test for 2 × 2 contingency tables using subsequent histologic analysis (11 lesions in 11 patients) or clinical course and MRI findings (29 lesions in 20 patients) as reference.Both TBR(max) and TBR(mean) were significantly higher in patients with recurrent metastasis (n = 19) than in patients with radiation necrosis (n = 21) (TBR(max), 3.2 ± 0.9 vs. 2.3 ± 0.5, P < 0.001; TBR(mean), 2.1 ± 0.4 vs. 1.8 ± 0.2, P < 0.001). The diagnostic accuracy of (18)F-FET PET for the correct identification of recurrent brain metastases reached 78% using TBR(max) (area under the ROC curve [AUC], 0.822 ± 0.07; sensitivity, 79%; specificity, 76%; cutoff, 2.55; P = 0.001), 83% using TBR(mean) (AUC, 0.851 ± 0.07; sensitivity, 74%; specificity, 90%; cutoff, 1.95; P < 0.001), and 92% for curve patterns II and III versus curve pattern I (sensitivity, 84%; specificity, 100%; P < 0.0001). The highest accuracy (93%) to diagnose local recurrent metastasis was obtained when both a TBR(mean) greater than 1.9 and curve pattern II or III were present (AUC, 0.959 ± 0.03; sensitivity, 95%; specificity, 91%; P < 0.001).Our findings suggest that the combined evaluation of the TBR(mean) of (18)F-FET uptake and the pattern of the time-activity curve can differentiate local brain metastasis recurrence from radionecrosis with high accuracy. (18)F-FET PET may thus contribute significantly to the management of patients with brain metastases.
KW  - Adolescent
KW  - Adult
KW  - Aged
KW  - Biological Transport
KW  - Brain Neoplasms: metabolism
KW  - Brain Neoplasms: radionuclide imaging
KW  - Brain Neoplasms: secondary
KW  - Diagnosis, Differential
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - Necrosis: metabolism
KW  - Necrosis: radionuclide imaging
KW  - Neoplasm Recurrence, Local: metabolism
KW  - Neoplasm Recurrence, Local: radionuclide imaging
KW  - Positron-Emission Tomography
KW  - ROC Curve
KW  - Radiation Injuries: metabolism
KW  - Radiation Injuries: radionuclide imaging
KW  - Tyrosine: analogs & derivatives
KW  - Tyrosine: diagnostic use
KW  - Tyrosine: metabolism
KW  - Young Adult
KW  - O-(2-fluoroethyl)tyrosine (NLM Chemicals)
KW  - Tyrosine (NLM Chemicals)
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
C6  - pmid:22872742
UR  - <Go to ISI:>//WOS:000308685100019
DO  - DOI:10.2967/jnumed.112.103325
UR  - https://juser.fz-juelich.de/record/22779
ER  -