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@ARTICLE{Savil:22784,
      author       = {Savil, M. and Bauer, A. and Mitterhauser, M. and Ding, Y.S.
                      and Hahn, A. and Kroll, T. and Neumeister, A. and Hauesler,
                      D. and et, al},
      title        = {{N}ormative database of the serotonergic system in healthy
                      subjects using multi-tracer {PET}},
      journal      = {NeuroImage},
      volume       = {63},
      issn         = {1053-8119},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {PreJuSER-22784},
      pages        = {447 - 459},
      year         = {2012},
      note         = {A. Hahn is recipient of a DOC-fellowship of the Austrian
                      Academy of Sciences at the Department of Psychiatry and
                      Psychotherapy, MUV. The other authors declare no conflict of
                      interest.This research was partly supported by grants from
                      the Austrian National Bank (OeNB13214 to R.L. and OeNB13675
                      M.M.), the Austrian Science Fund and by an unrestricted
                      investigator-initiated research grant from H. Lundbeck A/S
                      to S.K.A. Hahn is recipient of a DOC-fellowship of the
                      Austrian Academy of Sciences at the Department of Psychiatry
                      and Psychotherapy, MUV.},
      abstract     = {The highly diverse serotonergic system with at least 16
                      different receptor subtypes is implicated in the
                      pathophysiology of most neuropsychiatric disorders including
                      affective and anxiety disorders, obsessive compulsive
                      disorder, post-traumatic stress disorder, eating disorders,
                      sleep disturbance, attention deficit/hyperactivity disorder,
                      drug addiction, suicidal behavior, schizophrenia, Alzheimer,
                      etc. Alterations of the interplay between various pre- and
                      postsynaptic receptor subtypes might be involved in the
                      pathogenesis of these disorders. However, there is a lack of
                      comprehensive in vivo values using standardized procedures.
                      In the current PET study we quantified 3 receptor subtypes,
                      including the major inhibitory (5-HT(1A) and 5-HT(1B)) and
                      excitatory (5-HT(2A)) receptors, and the transporter (5-HTT)
                      in the brain of healthy human subjects to provide a database
                      of standard values. PET scans were performed on 95 healthy
                      subjects (age=28.0 ± 6.9 years; $59\%$ males) using the
                      selective radioligands [carbonyl-(11)C]WAY-100635,
                      [(11)C]P943, [(18)F]altanserin and [(11)C]DASB,
                      respectively. A standard template in MNI stereotactic space
                      served for region of interest delineation. This template
                      follows two anatomical parcellation schemes: 1) Brodmann
                      areas including 41 regions and 2) AAL (automated anatomical
                      labeling) including 52 regions. Standard values (mean, SD,
                      and range) for each receptor and region are presented. Mean
                      cortical and subcortical binding potential (BP) values were
                      in good agreement with previously published human in vivo
                      and post-mortem data. By means of linear equations, PET
                      binding potentials were translated to post-mortem binding
                      (provided in pmol/g), yielding 5.89 pmol/g (5-HT(1A)), 23.5
                      pmol/g (5-HT(1B)), 31.44 pmol/g (5-HT(2A)), and 11.33 pmol/g
                      (5-HTT) being equivalent to the BP of 1, respectively.
                      Furthermore, we computed individual voxel-wise maps with BP
                      values and generated average tracer-specific whole-brain
                      binding maps. This knowledge might improve our
                      interpretation of the alterations taking place in the
                      serotonergic system during neuropsychiatric disorders.},
      keywords     = {J (WoSType)},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      89571 - Connectivity and Activity (POF2-89571)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-HGF)POF2-89571},
      shelfmark    = {Neurosciences / Neuroimaging / Radiology, Nuclear Medicine
                      $\&$ Medical Imaging},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:22789740},
      UT           = {WOS:000308770300046},
      doi          = {10.1016/j.neuroimage.2012.07.001},
      url          = {https://juser.fz-juelich.de/record/22784},
}