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000022877 084__ $$2WoS$$aNeurosciences
000022877 084__ $$2WoS$$aPsychiatry
000022877 1001_ $$0P:(DE-HGF)0$$aBecker, B.$$b0
000022877 245__ $$aFear Processing and Social Networking in the Absence of a Functional Amygdala
000022877 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2012
000022877 300__ $$a70 - 77
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000022877 440_0 $$011361$$aBiological Psychiatry$$v72$$x0006-3223$$y1
000022877 500__ $$aRH was supported by a German Research Foundation (DFG) Grant (HU1302/2-2) and by a Starting Independent Researcher Grant (NEMO-Neuromodulation of Emotion) jointly provided by the Ministry of Innovation, Science, Research, and Technology of the German State of North Rhine-Westphalia and the University of Bonn. RH is senior author.
000022877 520__ $$aThe human amygdala plays a crucial role in processing social signals, such as face expressions, particularly fearful ones, and facilitates responses to them in face-sensitive cortical regions. This contributes to social competence and individual amygdala size correlates with that of social networks. While rare patients with focal bilateral amygdala lesion typically show impaired recognition of fearful faces, this deficit is variable, and an intriguing possibility is that other brain regions can compensate to support fear and social signal processing.To investigate the brain's functional compensation of selective bilateral amygdala damage, we performed a series of behavioral, psychophysiological, and functional magnetic resonance imaging experiments in two adult female monozygotic twins (patient 1 and patient 2) with equivalent, extensive bilateral amygdala pathology as a sequela of lipoid proteinosis due to Urbach-Wiethe disease.Patient 1, but not patient 2, showed preserved recognition of fearful faces, intact modulation of acoustic startle responses by fear-eliciting scenes, and a normal-sized social network. Functional magnetic resonance imaging revealed that patient 1 showed potentiated responses to fearful faces in her left premotor cortex face area and bilaterally in the inferior parietal lobule.The premotor cortex face area and inferior parietal lobule are both implicated in the cortical mirror-neuron system, which mediates learning of observed actions and may thereby promote both imitation and empathy. Taken together, our findings suggest that despite the pre-eminent role of the amygdala in processing social information, the cortical mirror-neuron system may sometimes adaptively compensate for its pathology.
000022877 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems (FUEK409)$$cFUEK409$$x0
000022877 536__ $$0G:(DE-Juel1)FUEK409$$2G:(DE-HGF)$$aFunktion und Dysfunktion des Nervensystems (FUEK409)$$cFUEK409$$x1
000022877 536__ $$0G:(DE-HGF)POF2-89573$$a89573 - Neuroimaging (POF2-89573)$$cPOF2-89573$$fPOF II T$$x2
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000022877 65320 $$2Author$$aAcoustic startle reflex
000022877 65320 $$2Author$$aamygdala lesion
000022877 65320 $$2Author$$acompensation
000022877 65320 $$2Author$$aemotion
000022877 65320 $$2Author$$aface
000022877 65320 $$2Author$$afear
000022877 65320 $$2Author$$afMRI
000022877 65320 $$2Author$$amirror-neuron system
000022877 65320 $$2Author$$asocial network
000022877 650_2 $$2MeSH$$aAdolescent
000022877 650_2 $$2MeSH$$aAmygdala: physiopathology
000022877 650_2 $$2MeSH$$aBrain: physiopathology
000022877 650_2 $$2MeSH$$aBrain Mapping: methods
000022877 650_2 $$2MeSH$$aEcho-Planar Imaging: methods
000022877 650_2 $$2MeSH$$aFacial Expression
000022877 650_2 $$2MeSH$$aFear: psychology
000022877 650_2 $$2MeSH$$aFemale
000022877 650_2 $$2MeSH$$aHumans
000022877 650_2 $$2MeSH$$aLipoid Proteinosis of Urbach and Wiethe: physiopathology
000022877 650_2 $$2MeSH$$aMagnetic Resonance Imaging: methods
000022877 650_2 $$2MeSH$$aMental Processes
000022877 650_2 $$2MeSH$$aRecognition (Psychology)
000022877 650_2 $$2MeSH$$aSocial Behavior
000022877 650_2 $$2MeSH$$aStartle Reaction
000022877 650_2 $$2MeSH$$aTwins, Monozygotic: psychology
000022877 650_7 $$2WoSType$$aJ
000022877 7001_ $$0P:(DE-HGF)0$$aMihov, Y.$$b1
000022877 7001_ $$0P:(DE-HGF)0$$aScheele, D.$$b2
000022877 7001_ $$0P:(DE-HGF)0$$aKendrick, K.M.$$b3
000022877 7001_ $$0P:(DE-HGF)0$$aFeinstein, J.S.$$b4
000022877 7001_ $$0P:(DE-Juel1)138474$$aMatusch, A.$$b5$$uFZJ
000022877 7001_ $$0P:(DE-HGF)0$$aAydin, M.$$b6
000022877 7001_ $$0P:(DE-HGF)0$$aReich, H.$$b7
000022877 7001_ $$0P:(DE-HGF)0$$aUrbach, H.$$b8
000022877 7001_ $$0P:(DE-Juel1)VDB65642$$aOros-Peusquens, A.M.$$b9$$uFZJ
000022877 7001_ $$0P:(DE-Juel1)131794$$aShah, N.J.$$b10$$uFZJ
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000022877 7001_ $$0P:(DE-HGF)0$$aSchlaepfer, T.E.$$b12
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000022877 7001_ $$0P:(DE-HGF)0$$aMaier, W.$$b14
000022877 7001_ $$0P:(DE-HGF)0$$aHurlemann, R.$$b15
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