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@ARTICLE{Becker:22877,
      author       = {Becker, B. and Mihov, Y. and Scheele, D. and Kendrick, K.M.
                      and Feinstein, J.S. and Matusch, A. and Aydin, M. and Reich,
                      H. and Urbach, H. and Oros-Peusquens, A.M. and Shah, N.J.
                      and Kunz, W.S. and Schlaepfer, T.E. and Zilles, K. and
                      Maier, W. and Hurlemann, R.},
      title        = {{F}ear {P}rocessing and {S}ocial {N}etworking in the
                      {A}bsence of a {F}unctional {A}mygdala},
      journal      = {Biological psychiatry},
      volume       = {72},
      issn         = {0006-3223},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {PreJuSER-22877},
      pages        = {70 - 77},
      year         = {2012},
      note         = {RH was supported by a German Research Foundation (DFG)
                      Grant (HU1302/2-2) and by a Starting Independent Researcher
                      Grant (NEMO-Neuromodulation of Emotion) jointly provided by
                      the Ministry of Innovation, Science, Research, and
                      Technology of the German State of North Rhine-Westphalia and
                      the University of Bonn. RH is senior author.},
      abstract     = {The human amygdala plays a crucial role in processing
                      social signals, such as face expressions, particularly
                      fearful ones, and facilitates responses to them in
                      face-sensitive cortical regions. This contributes to social
                      competence and individual amygdala size correlates with that
                      of social networks. While rare patients with focal bilateral
                      amygdala lesion typically show impaired recognition of
                      fearful faces, this deficit is variable, and an intriguing
                      possibility is that other brain regions can compensate to
                      support fear and social signal processing.To investigate the
                      brain's functional compensation of selective bilateral
                      amygdala damage, we performed a series of behavioral,
                      psychophysiological, and functional magnetic resonance
                      imaging experiments in two adult female monozygotic twins
                      (patient 1 and patient 2) with equivalent, extensive
                      bilateral amygdala pathology as a sequela of lipoid
                      proteinosis due to Urbach-Wiethe disease.Patient 1, but not
                      patient 2, showed preserved recognition of fearful faces,
                      intact modulation of acoustic startle responses by
                      fear-eliciting scenes, and a normal-sized social network.
                      Functional magnetic resonance imaging revealed that patient
                      1 showed potentiated responses to fearful faces in her left
                      premotor cortex face area and bilaterally in the inferior
                      parietal lobule.The premotor cortex face area and inferior
                      parietal lobule are both implicated in the cortical
                      mirror-neuron system, which mediates learning of observed
                      actions and may thereby promote both imitation and empathy.
                      Taken together, our findings suggest that despite the
                      pre-eminent role of the amygdala in processing social
                      information, the cortical mirror-neuron system may sometimes
                      adaptively compensate for its pathology.},
      keywords     = {Adolescent / Amygdala: physiopathology / Brain:
                      physiopathology / Brain Mapping: methods / Echo-Planar
                      Imaging: methods / Facial Expression / Fear: psychology /
                      Female / Humans / Lipoid Proteinosis of Urbach and Wiethe:
                      physiopathology / Magnetic Resonance Imaging: methods /
                      Mental Processes / Recognition (Psychology) / Social
                      Behavior / Startle Reaction / Twins, Monozygotic: psychology
                      / J (WoSType)},
      cin          = {INM-4 / INM-2},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-2-20090406},
      pnm          = {Funktion und Dysfunktion des Nervensystems (FUEK409) /
                      Funktion und Dysfunktion des Nervensystems (FUEK409) / 89573
                      - Neuroimaging (POF2-89573)},
      pid          = {G:(DE-Juel1)FUEK409 / G:(DE-Juel1)FUEK409 /
                      G:(DE-HGF)POF2-89573},
      shelfmark    = {Neurosciences / Psychiatry},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:22218285},
      UT           = {WOS:000305278800013},
      doi          = {10.1016/j.biopsych.2011.11.024},
      url          = {https://juser.fz-juelich.de/record/22877},
}