Hauptseite > Publikationsdatenbank > Fear Processing and Social Networking in the Absence of a Functional Amygdala > print

001     22877
005     20210129210833.0
024 7 _ |2 pmid
|a pmid:22218285
024 7 _ |2 DOI
|a 10.1016/j.biopsych.2011.11.024
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037 _ _ |a PreJuSER-22877
041 _ _ |a eng
082 _ _ |a 570
084 _ _ |2 WoS
|a Neurosciences
084 _ _ |2 WoS
|a Psychiatry
100 1 _ |0 P:(DE-HGF)0
|a Becker, B.
|b 0
245 _ _ |a Fear Processing and Social Networking in the Absence of a Functional Amygdala
260 _ _ |a Amsterdam [u.a.]
|b Elsevier Science
|c 2012
300 _ _ |a 70 - 77
336 7 _ |a Journal Article
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336 7 _ |a article
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440 _ 0 |0 11361
|a Biological Psychiatry
|v 72
|x 0006-3223
|y 1
500 _ _ |a RH was supported by a German Research Foundation (DFG) Grant (HU1302/2-2) and by a Starting Independent Researcher Grant (NEMO-Neuromodulation of Emotion) jointly provided by the Ministry of Innovation, Science, Research, and Technology of the German State of North Rhine-Westphalia and the University of Bonn. RH is senior author.
520 _ _ |a The human amygdala plays a crucial role in processing social signals, such as face expressions, particularly fearful ones, and facilitates responses to them in face-sensitive cortical regions. This contributes to social competence and individual amygdala size correlates with that of social networks. While rare patients with focal bilateral amygdala lesion typically show impaired recognition of fearful faces, this deficit is variable, and an intriguing possibility is that other brain regions can compensate to support fear and social signal processing.To investigate the brain's functional compensation of selective bilateral amygdala damage, we performed a series of behavioral, psychophysiological, and functional magnetic resonance imaging experiments in two adult female monozygotic twins (patient 1 and patient 2) with equivalent, extensive bilateral amygdala pathology as a sequela of lipoid proteinosis due to Urbach-Wiethe disease.Patient 1, but not patient 2, showed preserved recognition of fearful faces, intact modulation of acoustic startle responses by fear-eliciting scenes, and a normal-sized social network. Functional magnetic resonance imaging revealed that patient 1 showed potentiated responses to fearful faces in her left premotor cortex face area and bilaterally in the inferior parietal lobule.The premotor cortex face area and inferior parietal lobule are both implicated in the cortical mirror-neuron system, which mediates learning of observed actions and may thereby promote both imitation and empathy. Taken together, our findings suggest that despite the pre-eminent role of the amygdala in processing social information, the cortical mirror-neuron system may sometimes adaptively compensate for its pathology.
536 _ _ |0 G:(DE-Juel1)FUEK409
|2 G:(DE-HGF)
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|c FUEK409
|a Funktion und Dysfunktion des Nervensystems (FUEK409)
536 _ _ |0 G:(DE-Juel1)FUEK409
|2 G:(DE-HGF)
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|c FUEK409
|a Funktion und Dysfunktion des Nervensystems (FUEK409)
536 _ _ |0 G:(DE-HGF)POF2-89573
|a 89573 - Neuroimaging (POF2-89573)
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588 _ _ |a Dataset connected to Web of Science, Pubmed
650 _ 2 |2 MeSH
|a Adolescent
650 _ 2 |2 MeSH
|a Amygdala: physiopathology
650 _ 2 |2 MeSH
|a Brain: physiopathology
650 _ 2 |2 MeSH
|a Brain Mapping: methods
650 _ 2 |2 MeSH
|a Echo-Planar Imaging: methods
650 _ 2 |2 MeSH
|a Facial Expression
650 _ 2 |2 MeSH
|a Fear: psychology
650 _ 2 |2 MeSH
|a Female
650 _ 2 |2 MeSH
|a Humans
650 _ 2 |2 MeSH
|a Lipoid Proteinosis of Urbach and Wiethe: physiopathology
650 _ 2 |2 MeSH
|a Magnetic Resonance Imaging: methods
650 _ 2 |2 MeSH
|a Mental Processes
650 _ 2 |2 MeSH
|a Recognition (Psychology)
650 _ 2 |2 MeSH
|a Social Behavior
650 _ 2 |2 MeSH
|a Startle Reaction
650 _ 2 |2 MeSH
|a Twins, Monozygotic: psychology
650 _ 7 |2 WoSType
|a J
653 2 0 |2 Author
|a Acoustic startle reflex
653 2 0 |2 Author
|a amygdala lesion
653 2 0 |2 Author
|a compensation
653 2 0 |2 Author
|a emotion
653 2 0 |2 Author
|a face
653 2 0 |2 Author
|a fear
653 2 0 |2 Author
|a fMRI
653 2 0 |2 Author
|a mirror-neuron system
653 2 0 |2 Author
|a social network
700 1 _ |0 P:(DE-HGF)0
|a Mihov, Y.
|b 1
700 1 _ |0 P:(DE-HGF)0
|a Scheele, D.
|b 2
700 1 _ |0 P:(DE-HGF)0
|a Kendrick, K.M.
|b 3
700 1 _ |0 P:(DE-HGF)0
|a Feinstein, J.S.
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700 1 _ |0 P:(DE-Juel1)138474
|a Matusch, A.
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700 1 _ |0 P:(DE-HGF)0
|a Aydin, M.
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700 1 _ |0 P:(DE-HGF)0
|a Reich, H.
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700 1 _ |0 P:(DE-HGF)0
|a Urbach, H.
|b 8
700 1 _ |0 P:(DE-Juel1)VDB65642
|a Oros-Peusquens, A.M.
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700 1 _ |0 P:(DE-Juel1)131794
|a Shah, N.J.
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700 1 _ |0 P:(DE-HGF)0
|a Kunz, W.S.
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700 1 _ |0 P:(DE-HGF)0
|a Schlaepfer, T.E.
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700 1 _ |0 P:(DE-Juel1)131714
|a Zilles, K.
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700 1 _ |0 P:(DE-HGF)0
|a Maier, W.
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700 1 _ |0 P:(DE-HGF)0
|a Hurlemann, R.
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|a 10.1016/j.biopsych.2011.11.024
|g Vol. 72, p. 70 - 77
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|t Biological psychiatry
|v 72
|x 0006-3223
|y 2012
856 7 _ |u http://dx.doi.org/10.1016/j.biopsych.2011.11.024
909 C O |o oai:juser.fz-juelich.de:22877
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