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000022932 0247_ $$2pmid$$apmid:17645476
000022932 0247_ $$2DOI$$a10.1117/2.1201209.004470
000022932 037__ $$aPreJuSER-22932
000022932 041__ $$aeng
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000022932 1001_ $$0P:(DE-Juel1)VDB51558$$aMontzka, C.$$b0$$uFZJ
000022932 245__ $$aImproved remote sensing of surface soil moisture
000022932 260__ $$aBellingham, Wash.$$c2012
000022932 300__ $$a.
000022932 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article
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000022932 520__ $$aAs liver fibrosis is the result of persistent necroinflammation in the liver, pro-inflammatory cytokines secreted in response to cell injury have a central role in the pathogenesis of liver fibrosis. We aimed to investigate the association of cytokine gene polymorphism and liver fibrosis among Chinese patients with chronic hepatitis B.Polymorphisms at interleukin-10 (IL-10-627, -1117), interleukin-1-beta (IL-1beta-511, -31, -3964), interleukin-1 receptor antagonist (IL-1RN), and tumor necrosis factor-alpha (TNF-alpha-308, -238) among Chinese chronic hepatitis B patients were determined. Severe liver fibrosis was defined as Ishak fibrosis score = 4 (of 6).Fifty-nine of 273 (22%) patients had severe fibrosis. The distribution of genotypes for IL-10-627 was CC (11%), CA (41%), and AA (48%). The CC genotype at IL-10-627 was protective against severe fibrosis (odds ratio (OR) 0.11; 95% CI 0.014-0.82; P = 0.032). After adjusted for baseline variables, the adjusted OR of CC genotypes at IL-10-627 for severe fibrosis was 0.063 (95% CI 0.06-0.64; P = 0.063). Other gene polymorphisms at IL-1beta, IL-1RN, TNF-alpha, and IL-10 had no significant association with severe fibrosis. Weak linkage disequilibrium was observed between IL-10-627 and IL-10-1117 with linkage disequilibrium coefficient of 0.12 (P < 0.001). The distribution of haplotypes of IL-10-1117 and IL-10-627 was A-A (69%), A-C (26%), and G-C (5%). High and intermediate IL-10 production (A-C and G-C) haplotypes were protective against severe fibrosis (OR 0.62; 95% CI 0.39-0.99; P = 0.046).High production genotype and haplotypes of IL-10 were associated with less severe liver fibrosis in chronic hepatitis B in Chinese.
000022932 536__ $$0G:(DE-Juel1)FUEK407$$2G:(DE-HGF)$$aTerrestrische Umwelt$$cP24$$x0
000022932 588__ $$aDataset connected to Pubmed
000022932 650_2 $$2MeSH$$aAdult
000022932 650_2 $$2MeSH$$aFemale
000022932 650_2 $$2MeSH$$aHepatitis B, Chronic: complications
000022932 650_2 $$2MeSH$$aHumans
000022932 650_2 $$2MeSH$$aInterleukin 1 Receptor Antagonist Protein: genetics
000022932 650_2 $$2MeSH$$aInterleukin-10: genetics
000022932 650_2 $$2MeSH$$aInterleukin-1beta: genetics
000022932 650_2 $$2MeSH$$aLiver Cirrhosis: complications
000022932 650_2 $$2MeSH$$aLiver Cirrhosis: genetics
000022932 650_2 $$2MeSH$$aMale
000022932 650_2 $$2MeSH$$aPolymorphism, Genetic
000022932 650_2 $$2MeSH$$aTumor Necrosis Factor-alpha: genetics
000022932 650_7 $$00$$2NLM Chemicals$$aIL1RN protein, human
000022932 650_7 $$00$$2NLM Chemicals$$aInterleukin 1 Receptor Antagonist Protein
000022932 650_7 $$00$$2NLM Chemicals$$aInterleukin-1beta
000022932 650_7 $$00$$2NLM Chemicals$$aTumor Necrosis Factor-alpha
000022932 650_7 $$0130068-27-8$$2NLM Chemicals$$aInterleukin-10
000022932 7001_ $$0P:(DE-Juel1)129549$$aVereecken, H.$$b1$$uFZJ
000022932 773__ $$0PERI:(DE-600)2619543-4$$a10.1117/2.1201209.004470$$tSPIE newsroom$$x1818-2259$$y2012
000022932 8567_ $$uhttp://dx.doi.org/10.1117/2.1201209.004470
000022932 909CO $$ooai:juser.fz-juelich.de:22932$$pVDB
000022932 915__ $$0StatID:(DE-HGF)0040$$2StatID\$$aPeer Review unknown
000022932 9141_ $$y2012
000022932 9131_ $$0G:(DE-Juel1)FUEK407$$1G:(DE-HGF)POF2-240$$2G:(DE-HGF)POF2-200$$bErde und Umwelt$$kP24$$lTerrestrische Umwelt$$vTerrestrische Umwelt$$x0
000022932 9132_ $$0G:(DE-HGF)POF3-259H$$1G:(DE-HGF)POF3-250$$2G:(DE-HGF)POF3-200$$aDE-HGF$$bMarine, Küsten- und Polare Systeme$$lTerrestrische Umwelt$$vAddenda$$x0
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