TY  - JOUR
AU  - Montzka, C.
AU  - Vereecken, H.
TI  - Improved remote sensing of surface soil moisture
JO  - SPIE newsroom
VL  - .
SN  - 1818-2259
CY  - Bellingham, Wash.
M1  - PreJuSER-22932
SP  - .
PY  - 2012
N1  - Record converted from VDB: 12.11.2012
AB  - As liver fibrosis is the result of persistent necroinflammation in the liver, pro-inflammatory cytokines secreted in response to cell injury have a central role in the pathogenesis of liver fibrosis. We aimed to investigate the association of cytokine gene polymorphism and liver fibrosis among Chinese patients with chronic hepatitis B.Polymorphisms at interleukin-10 (IL-10-627, -1117), interleukin-1-beta (IL-1beta-511, -31, -3964), interleukin-1 receptor antagonist (IL-1RN), and tumor necrosis factor-alpha (TNF-alpha-308, -238) among Chinese chronic hepatitis B patients were determined. Severe liver fibrosis was defined as Ishak fibrosis score = 4 (of 6).Fifty-nine of 273 (22%) patients had severe fibrosis. The distribution of genotypes for IL-10-627 was CC (11%), CA (41%), and AA (48%). The CC genotype at IL-10-627 was protective against severe fibrosis (odds ratio (OR) 0.11; 95% CI 0.014-0.82; P = 0.032). After adjusted for baseline variables, the adjusted OR of CC genotypes at IL-10-627 for severe fibrosis was 0.063 (95% CI 0.06-0.64; P = 0.063). Other gene polymorphisms at IL-1beta, IL-1RN, TNF-alpha, and IL-10 had no significant association with severe fibrosis. Weak linkage disequilibrium was observed between IL-10-627 and IL-10-1117 with linkage disequilibrium coefficient of 0.12 (P < 0.001). The distribution of haplotypes of IL-10-1117 and IL-10-627 was A-A (69%), A-C (26%), and G-C (5%). High and intermediate IL-10 production (A-C and G-C) haplotypes were protective against severe fibrosis (OR 0.62; 95% CI 0.39-0.99; P = 0.046).High production genotype and haplotypes of IL-10 were associated with less severe liver fibrosis in chronic hepatitis B in Chinese.
KW  - Adult
KW  - Female
KW  - Hepatitis B, Chronic: complications
KW  - Humans
KW  - Interleukin 1 Receptor Antagonist Protein: genetics
KW  - Interleukin-10: genetics
KW  - Interleukin-1beta: genetics
KW  - Liver Cirrhosis: complications
KW  - Liver Cirrhosis: genetics
KW  - Male
KW  - Polymorphism, Genetic
KW  - Tumor Necrosis Factor-alpha: genetics
KW  - IL1RN protein, human (NLM Chemicals)
KW  - Interleukin 1 Receptor Antagonist Protein (NLM Chemicals)
KW  - Interleukin-1beta (NLM Chemicals)
KW  - Tumor Necrosis Factor-alpha (NLM Chemicals)
KW  - Interleukin-10 (NLM Chemicals)
LB  - PUB:(DE-HGF)16
C6  - pmid:17645476
DO  - DOI:10.1117/2.1201209.004470
UR  - https://juser.fz-juelich.de/record/22932
ER  -