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@ARTICLE{Montzka:22932,
      author       = {Montzka, C. and Vereecken, H.},
      title        = {{I}mproved remote sensing of surface soil moisture},
      journal      = {SPIE newsroom},
      volume       = {.},
      issn         = {1818-2259},
      address      = {Bellingham, Wash.},
      reportid     = {PreJuSER-22932},
      pages        = {.},
      year         = {2012},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {As liver fibrosis is the result of persistent
                      necroinflammation in the liver, pro-inflammatory cytokines
                      secreted in response to cell injury have a central role in
                      the pathogenesis of liver fibrosis. We aimed to investigate
                      the association of cytokine gene polymorphism and liver
                      fibrosis among Chinese patients with chronic hepatitis
                      B.Polymorphisms at interleukin-10 (IL-10-627, -1117),
                      interleukin-1-beta (IL-1beta-511, -31, -3964), interleukin-1
                      receptor antagonist (IL-1RN), and tumor necrosis
                      factor-alpha (TNF-alpha-308, -238) among Chinese chronic
                      hepatitis B patients were determined. Severe liver fibrosis
                      was defined as Ishak fibrosis score = 4 (of 6).Fifty-nine of
                      273 $(22\%)$ patients had severe fibrosis. The distribution
                      of genotypes for IL-10-627 was CC $(11\%),$ CA $(41\%),$ and
                      AA $(48\%).$ The CC genotype at IL-10-627 was protective
                      against severe fibrosis (odds ratio (OR) 0.11; $95\%$ CI
                      0.014-0.82; P = 0.032). After adjusted for baseline
                      variables, the adjusted OR of CC genotypes at IL-10-627 for
                      severe fibrosis was 0.063 $(95\%$ CI 0.06-0.64; P = 0.063).
                      Other gene polymorphisms at IL-1beta, IL-1RN, TNF-alpha, and
                      IL-10 had no significant association with severe fibrosis.
                      Weak linkage disequilibrium was observed between IL-10-627
                      and IL-10-1117 with linkage disequilibrium coefficient of
                      0.12 (P < 0.001). The distribution of haplotypes of
                      IL-10-1117 and IL-10-627 was A-A $(69\%),$ A-C $(26\%),$ and
                      G-C $(5\%).$ High and intermediate IL-10 production (A-C and
                      G-C) haplotypes were protective against severe fibrosis (OR
                      0.62; $95\%$ CI 0.39-0.99; P = 0.046).High production
                      genotype and haplotypes of IL-10 were associated with less
                      severe liver fibrosis in chronic hepatitis B in Chinese.},
      keywords     = {Adult / Female / Hepatitis B, Chronic: complications /
                      Humans / Interleukin 1 Receptor Antagonist Protein: genetics
                      / Interleukin-10: genetics / Interleukin-1beta: genetics /
                      Liver Cirrhosis: complications / Liver Cirrhosis: genetics /
                      Male / Polymorphism, Genetic / Tumor Necrosis Factor-alpha:
                      genetics / IL1RN protein, human (NLM Chemicals) /
                      Interleukin 1 Receptor Antagonist Protein (NLM Chemicals) /
                      Interleukin-1beta (NLM Chemicals) / Tumor Necrosis
                      Factor-alpha (NLM Chemicals) / Interleukin-10 (NLM
                      Chemicals)},
      cin          = {IBG-3},
      ddc          = {620},
      cid          = {I:(DE-Juel1)IBG-3-20101118},
      pnm          = {Terrestrische Umwelt},
      pid          = {G:(DE-Juel1)FUEK407},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:17645476},
      doi          = {10.1117/2.1201209.004470},
      url          = {https://juser.fz-juelich.de/record/22932},
}