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@ARTICLE{Polen:22961,
      author       = {Polen, T. and Rittmann, D. and Wendisch, V. F. and Sahm,
                      H.},
      title        = {{DNA} microarray analyses of the long-term adaptive
                      response of {E}scherichia coli to acetate and propionate},
      journal      = {Applied and environmental microbiology},
      volume       = {69},
      issn         = {0099-2240},
      address      = {Washington, DC [u.a.]},
      publisher    = {Soc.},
      reportid     = {PreJuSER-22961},
      pages        = {1759 - 1774},
      year         = {2003},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {In its natural environment, Escherichia coli is exposed to
                      short-chain fatty acids, such as acetic acid or propionic
                      acid, which can be utilized as carbon sources but which
                      inhibit growth at higher concentrations. DNA microarray
                      experiments revealed expression changes during exponential
                      growth on complex medium due to the presence of sodium
                      acetate or sodium propionate at a neutral external pH. The
                      adaptive responses to acetate and propionate were similar
                      and involved genes in three categories. First, the RNA
                      levels for chemotaxis and flagellum genes increased.
                      Accordingly, the expression of chromosomal fliC'-'lacZ and
                      flhDC'-'lacZ fusions and swimming motility increased after
                      adaptation to acetate or propionate. Second, the expression
                      of many genes that are involved in the uptake and
                      utilization of carbon sources decreased, indicating some
                      kind of catabolite repression by acetate and propionate.
                      Third, the expression of some genes of the general stress
                      response increased, but the increases were more pronounced
                      after short-term exposure for this response than for the
                      adaptive response. Adaptation to propionate but not to
                      acetate involved increased expression of threonine and
                      isoleucine biosynthetic genes. The gene expression changes
                      after adaptation to acetate or propionate were not caused
                      solely by uncoupling or osmotic effects but represented
                      specific characteristics of the long-term response of E.
                      coli to either compound.},
      keywords     = {J (WoSType)},
      cin          = {IBT-1},
      ddc          = {570},
      cid          = {I:(DE-Juel1)VDB55},
      pnm          = {Biotechnologie},
      pid          = {G:(DE-Juel1)FUEK256},
      shelfmark    = {Biotechnology $\&$ Applied Microbiology / Microbiology},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000181435600055},
      doi          = {10.1128/AEM.69.3.1759-1774.2003},
      url          = {https://juser.fz-juelich.de/record/22961},
}