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001     249493
005     20230210112355.0
024 7 _ |a G:(EU-Grant)639905
|d 639905
|2 CORDIS
024 7 _ |a G:(EU-Call)ERC-2014-STG
|d ERC-2014-STG
|2 CORDIS
024 7 _ |a corda__h2020::639905
|2 originalID
035 _ _ |a G:(EU-Grant)639905
150 _ _ |a Proteolytic processing in plant stress signal transduction and responses to abiotic stress and pathogen attack
|y 2015-06-01 - 2020-11-30
371 _ _ |a Forschungszentrum Jülich
|b Forschungszentrum Jülich
|d Germany
|e https://www.ptj.de/
|v CORDIS
372 _ _ |a ERC-2014-STG
|s 2015-06-01
|t 2020-11-30
450 _ _ |a ProPlantStress
|w d
|y 2015-06-01 - 2020-11-30
510 1 _ |0 I:(DE-588b)5098525-5
|a European Union
|2 CORDIS
680 _ _ |a Site-specific proteolytic processing is an irreversible post-translational protein modification that generates distinct protein species with new functions, interactions and subcellular locations. In plants, proteolytic processing regulates hormonal and stress signaling leading to adaptation of metabolic pathways and is implicated in plant-pathogen interactions. Despite their importance, proteolytic processes have largely been identified serendipitously, specific cleavage sites have rarely been identified and only a few of the hundreds of proteases encoded in plant genomes (>800 in Arabidopsis) have been linked to any substrates. Positional proteomics enables system-wide identification of proteolytic processing and protease substrate repertoires through quantitative determination of protein N- or C-termini. ProPlantStress will employ these approaches, which I co-developed during my postdoctoral research, to two linked abiotic and biotic stress conditions: i) Time-resolved mapping of chloroplast protein processing induced by high intensity light will reveal novel mechanisms of retrograde signal transduction, stress response and acclimation; ii) Profiling of protein processing triggered by pathogen recognition, combined with substrate identification for selected host and bacterial pathogen effector proteases will identify proteins with novel functions in plant immune responses and systemic signaling. Importantly, ProPlantStress will not merely catalogue termini and substrates: Mapping of cleavage sites to the protein domains and correlation with other modifications, such as phosphorylation, generates testable hypotheses on the function of processed protein species that will be examined in detail. ProPlantStress will thereby provide fundamental insights into proteolytic mechanisms underlying plant stress responses that are unattainable by other means. In the long term such knowledge is needed to develop new strategies for crop protection and mitigation of harvest loss.
909 C O |o oai:juser.fz-juelich.de:249493
|p authority:GRANT
|p authority
970 _ _ |a oai:dnet:corda__h2020::22fdecef50132348d2e1e5d8bab62c8a
980 _ _ |a G
980 _ _ |a CORDIS
980 _ _ |a AUTHORITY

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Marc 21