TY  - JOUR
AU  - Prechtel, K.
AU  - Bausch, A. R.
AU  - Marchi-Artzner, V.
AU  - Kantlehner, M.
AU  - Kessler, H.
AU  - Merkel, R.
TI  - Dynamic force spectroscopy to probe adhesion strength of living cells
JO  - Physical review letters
VL  - 89
SN  - 0031-9007
CY  - College Park, Md.
PB  - APS
M1  - PreJuSER-25196
SP  - 028101-1 - 028101-4
PY  - 2002
N1  - Record converted from VDB: 12.11.2012
AB  - We studied the mechanical strength of the adhesion of living cells to model membranes. The latter contained a RGD lipopeptide which is a high affinity binding site for a cell adhesion molecule (integrin alpha(V)beta(3)). Cells adhered specifically to the vesicles. We used micropipette aspiration for breaking this adhesion with well defined forces. Systematic variation of the rate of force application revealed pronounced kinetic effects. The dependence of the detachment forces on the loading rate was well described by a power law (exponent approximate to0.4), in agreement with recent theoretical work.
KW  - J (WoSType)
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000176420900033
DO  - DOI:10.1103/PhysRevLett.89.028101
UR  - https://juser.fz-juelich.de/record/25196
ER  -