001     25196
005     20200423203346.0
017 _ _ |a This version is available at the following Publisher URL: http://prl.aps.org
024 7 _ |a 10.1103/PhysRevLett.89.028101
|2 DOI
024 7 _ |a WOS:000176420900033
|2 WOS
024 7 _ |a 2128/2172
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037 _ _ |a PreJuSER-25196
041 _ _ |a eng
082 _ _ |a 550
084 _ _ |2 WoS
|a Physics, Multidisciplinary
100 1 _ |a Prechtel, K.
|b 0
|0 P:(DE-HGF)0
245 _ _ |a Dynamic force spectroscopy to probe adhesion strength of living cells
260 _ _ |a College Park, Md.
|b APS
|c 2002
300 _ _ |a 028101-1 - 028101-4
336 7 _ |a Journal Article
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336 7 _ |a ARTICLE
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336 7 _ |a JOURNAL_ARTICLE
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336 7 _ |a article
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440 _ 0 |a Physical Review Letters
|x 0031-9007
|0 4925
|v 89
500 _ _ |a Record converted from VDB: 12.11.2012
520 _ _ |a We studied the mechanical strength of the adhesion of living cells to model membranes. The latter contained a RGD lipopeptide which is a high affinity binding site for a cell adhesion molecule (integrin alpha(V)beta(3)). Cells adhered specifically to the vesicles. We used micropipette aspiration for breaking this adhesion with well defined forces. Systematic variation of the rate of force application revealed pronounced kinetic effects. The dependence of the detachment forces on the loading rate was well described by a power law (exponent approximate to0.4), in agreement with recent theoretical work.
536 _ _ |a Kondensierte Materie
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588 _ _ |a Dataset connected to Web of Science
650 _ 7 |a J
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700 1 _ |a Bausch, A. R.
|b 1
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700 1 _ |a Marchi-Artzner, V.
|b 2
|0 P:(DE-HGF)0
700 1 _ |a Kantlehner, M.
|b 3
|0 P:(DE-HGF)0
700 1 _ |a Kessler, H.
|b 4
|0 P:(DE-HGF)0
700 1 _ |a Merkel, R.
|b 5
|u FZJ
|0 P:(DE-Juel1)128833
773 _ _ |a 10.1103/PhysRevLett.89.028101
|g Vol. 89, p. 028101-1 - 028101-4
|p 028101-1 - 028101-4
|q 89<028101-1 - 028101-4
|0 PERI:(DE-600)1472655-5
|t Physical review letters
|v 89
|y 2002
|x 0031-9007
856 4 _ |u https://juser.fz-juelich.de/record/25196/files/16355.pdf
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914 1 _ |y 2002
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920 1 _ |k ISG-4
|l Institut für biologisch-anorganische Grenzflächen
|d 31.12.2001
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