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@ARTICLE{Kim:256093,
      author       = {Kim, Youngsoo and Elmenhorst, David and Weisshaupt, Angela
                      and Wedekind, Franziska and Kroll, Tina and Mccarley, Robert
                      W. and Strecker, Robert E. and Bauer, Andreas},
      title        = {{C}hronic sleep restriction induces long-lasting changes in
                      adenosine and noradrenaline receptor density in the rat
                      brain},
      journal      = {Journal of sleep research},
      volume       = {24},
      number       = {5},
      issn         = {0962-1105},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {FZJ-2015-06113},
      pages        = {549 - 558},
      year         = {2015},
      abstract     = {Although chronic sleep restriction frequently produces
                      long-lasting behavioural and physiological impairments in
                      humans, the underlying neural mechanisms are unknown. Here
                      we used a rat model of chronic sleep restriction to
                      investigate the role of brain adenosine and noradrenaline
                      systems, known to regulate sleep and wakefulness,
                      respectively. The density of adenosine A1 and A2a receptors
                      and β-adrenergic receptors before, during and following 5
                      days of sleep restriction was assessed with autoradiography.
                      Rats (n = 48) were sleep-deprived for 18 h day(-1) for 5
                      consecutive days (SR1-SR5), followed by 3 unrestricted
                      recovery sleep days (R1-R3). Brains were collected at the
                      beginning of the light period, which was immediately after
                      the end of sleep deprivation on sleep restriction days.
                      Chronic sleep restriction increased adenosine A1 receptor
                      density significantly in nine of the 13 brain areas analysed
                      with elevations also observed on R3 (+18 to $+32\%).$ In
                      contrast, chronic sleep restriction reduced adenosine A2a
                      receptor density significantly in one of the three brain
                      areas analysed (olfactory tubercle which declined $26-31\%$
                      from SR1 to R1). A decrease in β-adrenergic receptors
                      density was seen in substantia innominata and ventral
                      pallidum which remained reduced on R3, but no changes were
                      found in the anterior cingulate cortex. These data suggest
                      that chronic sleep restriction can induce long-term changes
                      in the brain adenosine and noradrenaline receptors, which
                      may underlie the long-lasting neurocognitive impairments
                      observed in chronic sleep restriction.},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571)},
      pid          = {G:(DE-HGF)POF3-571},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000363886100011},
      pubmed       = {pmid:25900125},
      doi          = {10.1111/jsr.12300},
      url          = {https://juser.fz-juelich.de/record/256093},
}