000256468 001__ 256468
000256468 005__ 20210129220725.0
000256468 0247_ $$2doi$$a10.1016/j.neuropsychologia.2015.09.017
000256468 0247_ $$2WOS$$aWOS:000363815500040
000256468 0247_ $$2altmetric$$aaltmetric:4533204
000256468 0247_ $$2pmid$$apmid:26382750
000256468 037__ $$aFZJ-2015-06373
000256468 041__ $$aEnglish
000256468 082__ $$a610
000256468 1001_ $$0P:(DE-HGF)0$$aSchönberger, A. R.$$b0
000256468 245__ $$aMotor loop dysfunction causes impaired cognitive sequencing in patients suffering from Parkinson's disease
000256468 260__ $$aAmsterdam [u.a.]$$bElsevier Science$$c2015
000256468 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1446559862_12656
000256468 3367_ $$2DataCite$$aOutput Types/Journal article
000256468 3367_ $$00$$2EndNote$$aJournal Article
000256468 3367_ $$2BibTeX$$aARTICLE
000256468 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000256468 3367_ $$2DRIVER$$aarticle
000256468 520__ $$aCognitive impairment in Parkinson's disease (PD) is often attributed to dopamine deficiency in the prefrontal-basal ganglia–thalamo-cortical loops. Although recent studies point to a close interplay between motor and cognitive abilities in PD, the so-called “motor loop” connecting supplementary motor area (SMA) and putamen has been considered solely with regard to the patients' motor impairment. Our study challenges this view by testing patients with the serial prediction task (SPT), a cognitive task that requires participants to predict stimulus sequences and particularly engages premotor sites of the motor loop. We hypothesised that affection of the motor loop causes impaired SPT performance, especially when the internal sequence representation is challenged by suspension of external stimuli. As shown for motor tasks, we further expected this impairment to be compensated by hyperactivity of the lateral premotor cortex (PM).We tested 16 male PD patients ON and OFF dopaminergic medication and 16 male age-matched healthy controls in an functional Magnetic Resonance Imaging study. All subjects performed two versions of the SPT: one with on-going sequences (SPT0), and one with sequences containing non-informative wildcards (SPT+) increasing the demands on mnemonic sequence representation. Patients ON (compared to controls) revealed an impaired performance coming along with hypoactivity of SMA and putamen. Patients OFF compared to ON medication, while showing poorer performance, exhibited a significantly increased PM activity for SPT+ vs. SPT0. Furthermore, patients' performance positively co-varied with PM activity, corroborating a compensatory account. Our data reveal a contribution of the motor loop to cognitive impairment in PD, and suggest a close interplay of SMA and PM beyond motor control.
000256468 536__ $$0G:(DE-HGF)POF3-572$$a572 - (Dys-)function and Plasticity (POF3-572)$$cPOF3-572$$fPOF III$$x0
000256468 7001_ $$0P:(DE-HGF)0$$aHagelweide, K.$$b1
000256468 7001_ $$0P:(DE-HGF)0$$aPelzer, E. A.$$b2
000256468 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon Rudolf$$b3
000256468 7001_ $$0P:(DE-HGF)0$$aSchubotz, Ricarda I.$$b4$$eCorresponding author
000256468 773__ $$0PERI:(DE-600)1500656-6$$a10.1016/j.neuropsychologia.2015.09.017$$p409-420$$tNeuropsychologia$$v77$$x0028-3932$$y2015
000256468 8564_ $$uhttps://juser.fz-juelich.de/record/256468/files/1-s2.0-S0028393215301603-main.pdf$$yRestricted
000256468 909CO $$ooai:juser.fz-juelich.de:256468$$pVDB
000256468 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131720$$aForschungszentrum Jülich GmbH$$b3$$kFZJ
000256468 9131_ $$0G:(DE-HGF)POF3-572$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$v(Dys-)function and Plasticity$$x0
000256468 9141_ $$y2015
000256468 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz
000256468 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000256468 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000256468 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNEUROPSYCHOLOGIA : 2014
000256468 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000256468 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000256468 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000256468 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000256468 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000256468 915__ $$0StatID:(DE-HGF)0130$$2StatID$$aDBCoverage$$bSocial Sciences Citation Index
000256468 915__ $$0StatID:(DE-HGF)1020$$2StatID$$aDBCoverage$$bCurrent Contents - Social and Behavioral Sciences
000256468 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000256468 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000256468 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5
000256468 920__ $$lyes
000256468 9201_ $$0I:(DE-Juel1)INM-3-20090406$$kINM-3$$lKognitive Neurowissenschaften$$x0
000256468 980__ $$ajournal
000256468 980__ $$aVDB
000256468 980__ $$aI:(DE-Juel1)INM-3-20090406
000256468 980__ $$aUNRESTRICTED