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@ARTICLE{Posse:27228,
      author       = {Posse, S. and Binkofski, F. and Schneider, F. and Gembris,
                      D. and Frings, W. and Habel, U. and Salloum, R. C. and
                      Mathiak, K. and Wiese, S. and Kiselev, V. and Graf, T. and
                      Elghahwagi, B. and Grosse-Ruyken, M. L. and Eickermann, T.},
      title        = {{A} new approach to measure single-event related brain
                      activity using real-time f{MRI} : feasibility of sensory,
                      motor, and higher congnitive tasks},
      journal      = {Human brain mapping},
      volume       = {12},
      issn         = {1065-9471},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {PreJuSER-27228},
      pages        = {25 - 41},
      year         = {2001},
      note         = {Record converted from VDB: 12.11.2012},
      abstract     = {Real-time fMRI is a rapidly emerging methodology that
                      enables monitoring changes in brain activity during an
                      ongoing experiment, in this article we demonstrate the
                      feasibility of performing single-event sensory, motor, and
                      higher cognitive tasks in real-time on a clinical whole-body
                      scanner. This approach requires sensitivity optimized fMRI
                      methods: Using statistical parametric mapping we quantified
                      the spatial extent of BOLD contrast signal changes as a
                      function of voxel size and demonstrate that sacrificing
                      spatial resolution and readout bandwidth improves the
                      detection of signal changes in real time. Further increases
                      in BOLD contrast sensitivity were obtained by using
                      real-time multi-echo EPI. Real-time image analysis was
                      performed using our previously described Functional imaging
                      in REal time (FIRE) software package, which features
                      real-time motion compensation, sliding window correlation
                      analysis, and automatic reference vector optimization. This
                      new fMRI methodology was validated using single-block design
                      paradigms of standard visual, motor, and auditory tasks.
                      Further, we demonstrate the sensitivity of this method for
                      online detection of higher cognitive functions during a
                      language task using single-block design paradigms. Finally,
                      we used single-event fMRI to characterize the variability of
                      the hemodynamic impulse response in primary and
                      supplementary motor cortex in consecutive trials using
                      single movements. Real-time fMRI can improve reliability of
                      clinical and research studies and offers new opportunities
                      for studying higher cognitive functions. (C) 2001
                      Wiley-Liss, Inc.},
      keywords     = {J (WoSType)},
      cin          = {ZAM / IME},
      ddc          = {610},
      cid          = {I:(DE-Juel1)VDB62 / I:(DE-Juel1)VDB54},
      pnm          = {Programmiermethoden und Software-Werkzeuge / Zerebrale
                      Repräsentation},
      pid          = {G:(DE-Juel1)FUEK106 / G:(DE-Juel1)FUEK90},
      shelfmark    = {Neurosciences / Neuroimaging / Radiology, Nuclear Medicine
                      $\&$ Medical Imaging},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000166179800003},
      doi          = {10.1002/1097-0193(200101)12:1<25::AID-HBM30>3.0.CO;2-H},
      url          = {https://juser.fz-juelich.de/record/27228},
}