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024 7 _ |2 DOI
|a 10.1002/1097-0193(200101)12:1<25::AID-HBM30>3.0.CO;2-H
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037 _ _ |a PreJuSER-27228
041 _ _ |a eng
082 _ _ |a 610
084 _ _ |2 WoS
|a Neurosciences
084 _ _ |2 WoS
|a Neuroimaging
084 _ _ |2 WoS
|a Radiology, Nuclear Medicine & Medical Imaging
100 1 _ |a Posse, S.
|0 P:(DE-Juel1)VDB1280
|b 0
|u FZJ
245 _ _ |a A new approach to measure single-event related brain activity using real-time fMRI : feasibility of sensory, motor, and higher congnitive tasks
260 _ _ |a New York, NY
|b Wiley-Liss
|c 2001
300 _ _ |a 25 - 41
336 7 _ |a Journal Article
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336 7 _ |a ARTICLE
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336 7 _ |a article
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440 _ 0 |a Human Brain Mapping
|x 1065-9471
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500 _ _ |a Record converted from VDB: 12.11.2012
520 _ _ |a Real-time fMRI is a rapidly emerging methodology that enables monitoring changes in brain activity during an ongoing experiment, in this article we demonstrate the feasibility of performing single-event sensory, motor, and higher cognitive tasks in real-time on a clinical whole-body scanner. This approach requires sensitivity optimized fMRI methods: Using statistical parametric mapping we quantified the spatial extent of BOLD contrast signal changes as a function of voxel size and demonstrate that sacrificing spatial resolution and readout bandwidth improves the detection of signal changes in real time. Further increases in BOLD contrast sensitivity were obtained by using real-time multi-echo EPI. Real-time image analysis was performed using our previously described Functional imaging in REal time (FIRE) software package, which features real-time motion compensation, sliding window correlation analysis, and automatic reference vector optimization. This new fMRI methodology was validated using single-block design paradigms of standard visual, motor, and auditory tasks. Further, we demonstrate the sensitivity of this method for online detection of higher cognitive functions during a language task using single-block design paradigms. Finally, we used single-event fMRI to characterize the variability of the hemodynamic impulse response in primary and supplementary motor cortex in consecutive trials using single movements. Real-time fMRI can improve reliability of clinical and research studies and offers new opportunities for studying higher cognitive functions. (C) 2001 Wiley-Liss, Inc.
536 _ _ |a Programmiermethoden und Software-Werkzeuge
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653 2 0 |2 Author
|a fMRI
653 2 0 |2 Author
|a real-time
653 2 0 |2 Author
|a single trial
653 2 0 |2 Author
|a event related
653 2 0 |2 Author
|a multi-echo
653 2 0 |2 Author
|a EPI
653 2 0 |2 Author
|a motor
653 2 0 |2 Author
|a visual
653 2 0 |2 Author
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653 2 0 |2 Author
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700 1 _ |a Binkofski, F.
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700 1 _ |a Schneider, F.
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700 1 _ |a Gembris, D.
|0 P:(DE-Juel1)VDB449
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700 1 _ |a Frings, W.
|0 P:(DE-Juel1)132108
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700 1 _ |a Habel, U.
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700 1 _ |a Salloum, R. C.
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700 1 _ |a Mathiak, K.
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700 1 _ |a Wiese, S.
|0 P:(DE-Juel1)VDB1777
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700 1 _ |a Kiselev, V.
|0 P:(DE-Juel1)VDB1974
|b 9
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700 1 _ |a Graf, T.
|0 P:(DE-Juel1)VDB1975
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700 1 _ |a Elghahwagi, B.
|0 P:(DE-Juel1)VDB342
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700 1 _ |a Grosse-Ruyken, M. L.
|0 P:(DE-Juel1)VDB508
|b 12
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700 1 _ |a Eickermann, T.
|0 P:(DE-Juel1)132091
|b 13
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773 _ _ |a 10.1002/1097-0193(200101)12:1<25::AID-HBM30>3.0.CO;2-H
|g Vol. 12, p. 25 - 41
|p 25 - 41
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|0 PERI:(DE-600)1492703-2
|t Human brain mapping
|v 12
|y 2001
|x 1065-9471
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914 1 _ |y 2001
915 _ _ |0 StatID:(DE-HGF)0010
|a JCR/ISI refereed
920 1 _ |k ZAM
|l Zentralinstitut für Angewandte Mathematik
|d 31.12.2007
|g ZAM
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920 1 _ |k IME
|l Institut für Medizin
|d 31.12.2006
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