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@ARTICLE{Monzel:276351,
      author       = {Monzel, C. and Schmidt, D. and Kleusch, C. and
                      Kirchenbüchler, D. and Seifert, U. and Smith, A-S and
                      Sengupta, K. and Merkel, Rudolf},
      title        = {{M}easuring fast stochastic displacements of bio-membranes
                      with dynamic optical displacement spectroscopy},
      journal      = {Nature Communications},
      volume       = {6},
      issn         = {2041-1723},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {FZJ-2015-06811},
      pages        = {8162 -},
      year         = {2015},
      abstract     = {Stochastic displacements or fluctuations of biological
                      membranes are increasingly recognized as an important aspect
                      of many physiological processes, but hitherto their precise
                      quantification in living cells was limited due to a lack of
                      tools to accurately record them. Here we introduce a novel
                      technique—dynamic optical displacement spectroscopy
                      (DODS), to measure stochastic displacements of membranes
                      with unprecedented combined spatiotemporal resolution of
                      20 nm and 10 μs. The technique was validated by
                      measuring bending fluctuations of model membranes. DODS was
                      then used to explore the fluctuations in human red blood
                      cells, which showed an ATP-induced enhancement of
                      non-Gaussian behaviour. Plasma membrane fluctuations of
                      human macrophages were quantified to this accuracy for the
                      first time. Stimulation with a cytokine enhanced
                      non-Gaussian contributions to these fluctuations. Simplicity
                      of implementation, and high accuracy make DODS a promising
                      tool for comprehensive understanding of stochastic membrane
                      processes.},
      cin          = {ICS-7},
      ddc          = {500},
      cid          = {I:(DE-Juel1)ICS-7-20110106},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000364919400001},
      pubmed       = {pmid:26437911},
      doi          = {10.1038/ncomms9162},
      url          = {https://juser.fz-juelich.de/record/276351},
}