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@INPROCEEDINGS{Schrader:276448,
      author       = {Schrader, Tobias Erich and Ostermann, Andreas and
                      Monkenbusch, Michael and Laatsch, Bernhard and Jüttner,
                      Philipp and Petry, Winfried and Richter, Dieter},
      title        = {{B}io{D}iff - a neutron diffractometer optimized for
                      crystals with largeunit cell dimensions},
      reportid     = {FZJ-2015-06887},
      year         = {2015},
      abstract     = {The newly built neutron single crystal diffractometer
                      BIODIFF at the research reactor Heinz Maier-Leibnitz (FRM
                      II) is especially designed to collect data from crystals
                      with large unit cells. The main field of application is the
                      structural analysis of proteins, especially the
                      determination of hydrogen atom positions. BIODIFF is a joint
                      project of the Jülich Centre for Neutron Science (JCNS) and
                      the FRM II. Typical scientific questions addressed are the
                      determination of protonation states of amino acid side
                      chains and the characterization of the hydrogen bonding
                      network between the protein active centre and an inhibitor
                      or substrate. BIODIFF (see picture below) is designed as a
                      monochromatic instrument with a narrow wavelength spread of
                      less than 3 $\%.$ By using a highly orientated pyrolytic
                      graphite monochromator (PG002) the diffractometer is able to
                      change its central wavelength in the range between 2.4 Å
                      and 5.6 Å. Contaminations of higher order wavelengths are
                      removed by a neutron velocity selector. To cover a large
                      solid angle the main detector of BIODIFF consists of a
                      neutron imaging plate in a cylindrical geometry with online
                      read-out capability. With a radius of 200 mm and a height of
                      450 mm it covers a solid angle of approximately 2π with a
                      spatial resolution of up to 125 µm. A fast Li/ZnS
                      scintillator CCD camera is available for additional
                      detection abilities. An optical CCD-camera pointing at the
                      sample position is used to quickly align the sample with
                      respect to the neutron beam. The main advantage of BIODIFF
                      is the possibility to adapt the wavelength to the size of
                      the unit cell of the sample crystal while operating with a
                      cleanmonochromatic beam that keeps the background level low.
                      BIODFF is equipped with a standard Oxford Cryosystem
                      “Cryostream 700+” which allows measurements in the
                      temperature range from 90 K up to 500 K. A standard closed
                      cycle cryostat is also available for measurements down to 4
                      K in vacuum. This may be used for the determination of
                      magnetic unit cells of inorganic crystals in zero magnetic
                      field. Recent applications of BIODIFF also include clay
                      powder diffraction and diffraction from lipid membranes in a
                      controlled humidity environment.},
      month         = {Aug},
      date          = {2015-08-30},
      organization  = {ECNS - European Conference on Neutron
                       Scattering, Zaragoza (Spain), 30 Aug
                       2015 - 4 Sep 2015},
      cin          = {JCNS (München) ; Jülich Centre for Neutron Science JCNS
                      (München) ; JCNS-FRM-II / Neutronenstreuung ; JCNS-1 /
                      ZEA-1},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106 / I:(DE-Juel1)ZEA-1-20090406},
      pnm          = {6215 - Soft Matter, Health and Life Sciences (POF3-621) /
                      6G15 - FRM II / MLZ (POF3-6G15) / 6G4 - Jülich Centre for
                      Neutron Research (JCNS) (POF3-623)},
      pid          = {G:(DE-HGF)POF3-6215 / G:(DE-HGF)POF3-6G15 /
                      G:(DE-HGF)POF3-6G4},
      experiment   = {EXP:(DE-MLZ)BIODIFF-20140101},
      typ          = {PUB:(DE-HGF)24},
      url          = {https://juser.fz-juelich.de/record/276448},
}