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000276568 1001_ $$0P:(DE-HGF)0$$aBrener, Oleksandr$$b0
000276568 245__ $$aQIAD assay for quantitating a compound’s efficacy in elimination of toxic Aβ oligomers
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000276568 520__ $$aStrong evidence exists for a central role of amyloid β-protein (Aβ) oligomers in the pathogenesis of Alzheimer’s disease. We have developed a fast, reliable and robust in vitro assay, termed QIAD, to quantify the effect of any compound on the Aβ aggregate size distribution. Applying QIAD, we studied the effect of homotaurine, scyllo-inositol, EGCG, the benzofuran derivative KMS88009, ZAβ3W, the D-enantiomeric peptide D3 and its tandem version D3D3 on Aβ aggregation. The predictive power of the assay for in vivo efficacy is demonstrated by comparing the oligomer elimination efficiency of D3 and D3D3 with their treatment effects in animal models of Alzheimer´s disease.
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000276568 7001_ $$0P:(DE-Juel1)145867$$aDunkelmann, Tina$$b1$$ufzj
000276568 7001_ $$0P:(DE-Juel1)145165$$aGremer, Lothar$$b2$$ufzj
000276568 7001_ $$0P:(DE-HGF)0$$avan Groen, Thomas$$b3
000276568 7001_ $$0P:(DE-HGF)0$$aMirecka, Ewa A.$$b4
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000276568 7001_ $$0P:(DE-Juel1)144347$$aWilluweit, Antje$$b6$$ufzj
000276568 7001_ $$0P:(DE-Juel1)159137$$aKutzsche, Janine$$b7$$ufzj
000276568 7001_ $$0P:(DE-Juel1)144626$$aJürgens, Dagmar$$b8$$ufzj
000276568 7001_ $$0P:(DE-Juel1)144116$$aRudolph, Stephan$$b9
000276568 7001_ $$0P:(DE-Juel1)131709$$aTusche, Markus$$b10$$ufzj
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000276568 7001_ $$0P:(DE-Juel1)131777$$aLangen, Karl-Josef$$b14$$ufzj
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000276568 7001_ $$0P:(DE-HGF)0$$aJanssen, Arnold$$b16
000276568 7001_ $$0P:(DE-Juel1)166306$$aHoyer, Wolfgang$$b17$$ufzj
000276568 7001_ $$0P:(DE-HGF)0$$aFunke, Susanne A.$$b18
000276568 7001_ $$0P:(DE-Juel1)162443$$aNagel-Steger, Luitgard$$b19$$ufzj
000276568 7001_ $$0P:(DE-Juel1)132029$$aWillbold, Dieter$$b20$$eCorresponding author$$ufzj
000276568 773__ $$0PERI:(DE-600)2615211-3$$a10.1038/srep13222$$gVol. 5, p. 13222 -$$p13222$$tScientific reports$$v5$$x2045-2322$$y2015
000276568 8564_ $$uhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585794/
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