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@ARTICLE{Brener:276568,
      author       = {Brener, Oleksandr and Dunkelmann, Tina and Gremer, Lothar
                      and van Groen, Thomas and Mirecka, Ewa A. and Kadish, Inga
                      and Willuweit, Antje and Kutzsche, Janine and Jürgens,
                      Dagmar and Rudolph, Stephan and Tusche, Markus and Bongen,
                      Patrick and Pietruszka, Jörg and Oesterhelt, Filipp and
                      Langen, Karl-Josef and Demuth, Hans-Ulrich and Janssen,
                      Arnold and Hoyer, Wolfgang and Funke, Susanne A. and
                      Nagel-Steger, Luitgard and Willbold, Dieter},
      title        = {{QIAD} assay for quantitating a compound’s efficacy in
                      elimination of toxic {A}β oligomers},
      journal      = {Scientific reports},
      volume       = {5},
      issn         = {2045-2322},
      address      = {London},
      publisher    = {Nature Publishing Group},
      reportid     = {FZJ-2015-06933},
      pages        = {13222},
      year         = {2015},
      abstract     = {Strong evidence exists for a central role of amyloid
                      β-protein (Aβ) oligomers in the pathogenesis of
                      Alzheimer’s disease. We have developed a fast, reliable
                      and robust in vitro assay, termed QIAD, to quantify the
                      effect of any compound on the Aβ aggregate size
                      distribution. Applying QIAD, we studied the effect of
                      homotaurine, scyllo-inositol, EGCG, the benzofuran
                      derivative KMS88009, ZAβ3W, the D-enantiomeric peptide D3
                      and its tandem version D3D3 on Aβ aggregation. The
                      predictive power of the assay for in vivo efficacy is
                      demonstrated by comparing the oligomer elimination
                      efficiency of D3 and D3D3 with their treatment effects in
                      animal models of Alzheimer´s disease.},
      cin          = {ICS-6 / IBOC / IBG-1},
      ddc          = {000},
      cid          = {I:(DE-Juel1)ICS-6-20110106 / I:(DE-Juel1)IBOC-20090406 /
                      I:(DE-Juel1)IBG-1-20101118},
      pnm          = {553 - Physical Basis of Diseases (POF3-553) / 581 -
                      Biotechnology (POF3-581)},
      pid          = {G:(DE-HGF)POF3-553 / G:(DE-HGF)POF3-581},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000361591400001},
      pubmed       = {pmid:26394756},
      doi          = {10.1038/srep13222},
      url          = {https://juser.fz-juelich.de/record/276568},
}