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000276569 245__ $$aConformational Polymorphism in Autophagy-Related Protein GATE-16
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000276569 520__ $$aAutophagy is a fundamental homeostatic process in eukaryotic organisms, fulfilling essential roles in development and adaptation to stress. Among other factors, formation of autophagosomes critically depends on proteins of the Atg8 (autophagy-related protein 8) family, which are reversibly conjugated to membrane lipids. We have applied Xray crystallography, nuclear magnetic resonance spectroscopy, and molecular dynamics simulations to study the conformational dynamics of Atg8-type proteins, using GATE-16 (Golgiassociated ATPase enhancer of 16 kDa), also known as GABARAPL2, as a model system. This combination of complementary approaches provides new insight into a structural transition centered on the C-terminus, which is crucial for the biological activity of these proteins.
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000276569 7001_ $$0P:(DE-Juel1)157850$$aSchillinger, Oliver$$b1$$ufzj
000276569 7001_ $$0P:(DE-Juel1)132019$$aSchwarten, Melanie$$b2$$ufzj
000276569 7001_ $$0P:(DE-Juel1)132010$$aLecher, Justin$$b3$$ufzj
000276569 7001_ $$0P:(DE-Juel1)132001$$aHartmann, Rudolf$$b4$$ufzj
000276569 7001_ $$0P:(DE-Juel1)132023$$aStoldt, Matthias$$b5$$ufzj
000276569 7001_ $$0P:(DE-Juel1)132012$$aMohrlüder, Jeannine$$b6$$ufzj
000276569 7001_ $$0P:(DE-Juel1)138971$$aOlubiyi, Olujide$$b7
000276569 7001_ $$0P:(DE-Juel1)132024$$aStrodel, Birgit$$b8$$ufzj
000276569 7001_ $$0P:(DE-Juel1)132029$$aWillbold, Dieter$$b9$$ufzj
000276569 7001_ $$0P:(DE-Juel1)131988$$aWeiergräber, Oliver H.$$b10$$eCorresponding author$$ufzj
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