TY  - JOUR
AU  - Ma, Peixiang
AU  - Schillinger, Oliver
AU  - Schwarten, Melanie
AU  - Lecher, Justin
AU  - Hartmann, Rudolf
AU  - Stoldt, Matthias
AU  - Mohrlüder, Jeannine
AU  - Olubiyi, Olujide
AU  - Strodel, Birgit
AU  - Willbold, Dieter
AU  - Weiergräber, Oliver H.
TI  - Conformational Polymorphism in Autophagy-Related Protein GATE-16
JO  - Biochemistry
VL  - 54
IS  - 35
SN  - 1520-4995
CY  - Columbus, Ohio
PB  - American Chemical Society
M1  - FZJ-2015-06934
SP  - 5469 - 5479
PY  - 2015
AB  - Autophagy is a fundamental homeostatic process in eukaryotic organisms, fulfilling essential roles in development and adaptation to stress. Among other factors, formation of autophagosomes critically depends on proteins of the Atg8 (autophagy-related protein 8) family, which are reversibly conjugated to membrane lipids. We have applied Xray crystallography, nuclear magnetic resonance spectroscopy, and molecular dynamics simulations to study the conformational dynamics of Atg8-type proteins, using GATE-16 (Golgiassociated ATPase enhancer of 16 kDa), also known as GABARAPL2, as a model system. This combination of complementary approaches provides new insight into a structural transition centered on the C-terminus, which is crucial for the biological activity of these proteins.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000361086500009
C6  - pmid:26284781
DO  - DOI:10.1021/acs.biochem.5b00366
UR  - https://juser.fz-juelich.de/record/276569
ER  -