Home > Publications database > Resonance assignment of the ligand-free cyclic nucleotide-binding domain from the murine ion channel HCN$_{2}$ > print

001     276620
005     20210129220921.0
024 7 _ |a 10.1007/s12104-014-9583-x
|2 doi
024 7 _ |a 1874-270X
|2 ISSN
024 7 _ |a 1874-2718
|2 ISSN
024 7 _ |a WOS:000361440100005
|2 WOS
037 _ _ |a FZJ-2015-06965
082 _ _ |a 570
100 1 _ |a Börger, Claudia
|0 P:(DE-Juel1)144025
|b 0
245 _ _ |a Resonance assignment of the ligand-free cyclic nucleotide-binding domain from the murine ion channel HCN$_{2}$
260 _ _ |a Dordrecht [u.a.]
|c 2015
|b Springer Netherlands
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1449666885_32512
|2 PUB:(DE-HGF)
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|0 0
|2 EndNote
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a article
|2 DRIVER
520 _ _ |a Hyperpolarization activated and cyclic nucleotide-gated (HCN) ion channels as well as cyclic nucleotide-gated (CNG) ion channels are essential for the regulation of cardiac cells, neuronal excitability, and signaling in sensory cells. Both classes are composed of four subunits. Each subunit comprises a transmembrane region, intracellular N- and C-termini, and a C-terminal cyclic nucleotide-binding domain (CNBD). Binding of cyclic nucleotides to the CNBD promotes opening of both CNG and HCN channels. In case of CNG channels, binding of cyclic nucleotides to the CNBD is sufficient to open the channel. In contrast, HCN channels open upon membrane hyperpolarization and their activity is modulated by binding of cyclic nucleotides shifting the activation potential to more positive values. Although several high-resolution structures of CNBDs from HCN and CNG channels are available, the gating mechanism for murine HCN2 channel, which leads to the opening of the channel pore, is still poorly understood. As part of a structural investigation, here, we report the complete backbone and side chain resonance assignments of the murine HCN2 CNBD with part of the C-linker.
536 _ _ |a 551 - Functional Macromolecules and Complexes (POF3-551)
|0 G:(DE-HGF)POF3-551
|c POF3-551
|f POF III
|x 0
588 _ _ |a Dataset connected to CrossRef
700 1 _ |a Schünke, Sven
|0 P:(DE-Juel1)132020
|b 1
700 1 _ |a Lecher, Justin
|0 P:(DE-Juel1)132010
|b 2
|u fzj
700 1 _ |a Stoldt, Matthias
|0 P:(DE-Juel1)132023
|b 3
|u fzj
700 1 _ |a Winkhaus, Friederike
|0 P:(DE-HGF)0
|b 4
700 1 _ |a Kaupp, U. Benjamin
|0 P:(DE-HGF)0
|b 5
700 1 _ |a Willbold, Dieter
|0 P:(DE-Juel1)132029
|b 6
|e Corresponding author
|u fzj
773 _ _ |a 10.1007/s12104-014-9583-x
|g Vol. 9, no. 2, p. 243 - 246
|0 PERI:(DE-600)2388861-1
|n 2
|p 243 - 246
|t Biomolecular NMR assignments
|v 9
|y 2015
|x 1874-270X
856 4 _ |u https://juser.fz-juelich.de/record/276620/files/Resonance%20assignment%20of%20the%20ligand-free%20cyclic%20nucleotide-binding%20domain%20from%20the%20murine%20ion%20channel%20HCN2.pdf
|y Restricted
856 4 _ |u https://juser.fz-juelich.de/record/276620/files/Resonance%20assignment%20of%20the%20ligand-free%20cyclic%20nucleotide-binding%20domain%20from%20the%20murine%20ion%20channel%20HCN2.gif?subformat=icon
|x icon
|y Restricted
856 4 _ |u https://juser.fz-juelich.de/record/276620/files/Resonance%20assignment%20of%20the%20ligand-free%20cyclic%20nucleotide-binding%20domain%20from%20the%20murine%20ion%20channel%20HCN2.jpg?subformat=icon-1440
|x icon-1440
|y Restricted
856 4 _ |u https://juser.fz-juelich.de/record/276620/files/Resonance%20assignment%20of%20the%20ligand-free%20cyclic%20nucleotide-binding%20domain%20from%20the%20murine%20ion%20channel%20HCN2.jpg?subformat=icon-180
|x icon-180
|y Restricted
856 4 _ |u https://juser.fz-juelich.de/record/276620/files/Resonance%20assignment%20of%20the%20ligand-free%20cyclic%20nucleotide-binding%20domain%20from%20the%20murine%20ion%20channel%20HCN2.jpg?subformat=icon-640
|x icon-640
|y Restricted
856 4 _ |u https://juser.fz-juelich.de/record/276620/files/Resonance%20assignment%20of%20the%20ligand-free%20cyclic%20nucleotide-binding%20domain%20from%20the%20murine%20ion%20channel%20HCN2.pdf?subformat=pdfa
|x pdfa
|y Restricted
909 C O |o oai:juser.fz-juelich.de:276620
|p VDB
910 1 _ |a Forschungszentrum Jülich GmbH
|0 I:(DE-588b)5008462-8
|k FZJ
|b 2
|6 P:(DE-Juel1)132010
910 1 _ |a Forschungszentrum Jülich GmbH
|0 I:(DE-588b)5008462-8
|k FZJ
|b 3
|6 P:(DE-Juel1)132023
910 1 _ |a Forschungszentrum Jülich GmbH
|0 I:(DE-588b)5008462-8
|k FZJ
|b 6
|6 P:(DE-Juel1)132029
913 1 _ |a DE-HGF
|b Key Technologies
|l BioSoft – Fundamentals for future Technologies in the fields of Soft Matter and Life Sciences
|1 G:(DE-HGF)POF3-550
|0 G:(DE-HGF)POF3-551
|2 G:(DE-HGF)POF3-500
|v Functional Macromolecules and Complexes
|x 0
|4 G:(DE-HGF)POF
|3 G:(DE-HGF)POF3
914 1 _ |y 2015
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b BIOMOL NMR ASSIGN : 2014
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0310
|2 StatID
|b NCBI Molecular Biology Database
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Thomson Reuters Master Journal List
915 _ _ |a WoS
|0 StatID:(DE-HGF)0111
|2 StatID
|b Science Citation Index Expanded
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
915 _ _ |a IF < 5
|0 StatID:(DE-HGF)9900
|2 StatID
920 _ _ |l yes
920 1 _ |0 I:(DE-Juel1)ICS-6-20110106
|k ICS-6
|l Strukturbiochemie
|x 0
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a I:(DE-Juel1)ICS-6-20110106
980 _ _ |a UNRESTRICTED
981 _ _ |a I:(DE-Juel1)IBI-7-20200312

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21