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000276643 1001_ $$0P:(DE-Juel1)140558$$aHung, Yu-Fu$$b0
000276643 245__ $$aAmino Terminal Region of Dengue Virus NS4A Cytosolic Domain Binds to Highly Curved Liposomes
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000276643 520__ $$aDengue virus (DENV) is an important human pathogen causing millions of disease cases and thousands of deaths worldwide. Non-structural protein 4A (NS4A) is a vital component of the viral replication complex (RC) and plays a major role in the formation of host cell membrane-derived structures that provide a scaffold for replication. The N-terminal cytoplasmic region of NS4A(1–48) is known to preferentially interact with highly curved membranes. Here, we provide experimental evidence for the stable binding of NS4A(1–48) to small liposomes using a liposome floatation assay and identify the lipid binding sequence by NMR spectroscopy. Mutations L6E;M10E were previously shown to inhibit DENV replication and to interfere with the binding of NS4A(1–48) to small liposomes. Our results provide new details on the interaction of the N-terminal region of NS4A with membranes and will prompt studies of the functional relevance of the curvature sensitive membrane anchor at the N-terminus of NS4A.
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000276643 7001_ $$0P:(DE-Juel1)132019$$aSchwarten, Melanie$$b1$$ufzj
000276643 7001_ $$0P:(DE-Juel1)132003$$aHoffmann, Silke$$b2$$ufzj
000276643 7001_ $$0P:(DE-Juel1)132029$$aWillbold, Dieter$$b3$$ufzj
000276643 7001_ $$0P:(DE-HGF)0$$aSklan, Ella$$b4
000276643 7001_ $$0P:(DE-Juel1)132009$$aKönig, Bernd$$b5$$eCorresponding author$$ufzj
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