Hauptseite > Workflowsammlungen > Öffentliche Einträge > Amino Terminal Region of Dengue Virus NS4A Cytosolic Domain Binds to Highly Curved Liposomes > print

001     276643
005     20220930130052.0
024 7 _ |a 10.3390/v7072812
|2 doi
024 7 _ |a 2128/9547
|2 Handle
024 7 _ |a WOS:000360353200038
|2 WOS
024 7 _ |a altmetric:4303569
|2 altmetric
024 7 _ |a pmid:26197333
|2 pmid
037 _ _ |a FZJ-2015-06971
082 _ _ |a 610
100 1 _ |a Hung, Yu-Fu
|0 P:(DE-Juel1)140558
|b 0
245 _ _ |a Amino Terminal Region of Dengue Virus NS4A Cytosolic Domain Binds to Highly Curved Liposomes
260 _ _ |a Basel
|c 2015
|b MDPI
336 7 _ |a Journal Article
|b journal
|m journal
|0 PUB:(DE-HGF)16
|s 1449669731_32514
|2 PUB:(DE-HGF)
336 7 _ |a Output Types/Journal article
|2 DataCite
336 7 _ |a Journal Article
|0 0
|2 EndNote
336 7 _ |a ARTICLE
|2 BibTeX
336 7 _ |a JOURNAL_ARTICLE
|2 ORCID
336 7 _ |a article
|2 DRIVER
520 _ _ |a Dengue virus (DENV) is an important human pathogen causing millions of disease cases and thousands of deaths worldwide. Non-structural protein 4A (NS4A) is a vital component of the viral replication complex (RC) and plays a major role in the formation of host cell membrane-derived structures that provide a scaffold for replication. The N-terminal cytoplasmic region of NS4A(1–48) is known to preferentially interact with highly curved membranes. Here, we provide experimental evidence for the stable binding of NS4A(1–48) to small liposomes using a liposome floatation assay and identify the lipid binding sequence by NMR spectroscopy. Mutations L6E;M10E were previously shown to inhibit DENV replication and to interfere with the binding of NS4A(1–48) to small liposomes. Our results provide new details on the interaction of the N-terminal region of NS4A with membranes and will prompt studies of the functional relevance of the curvature sensitive membrane anchor at the N-terminus of NS4A.
536 _ _ |a 553 - Physical Basis of Diseases (POF3-553)
|0 G:(DE-HGF)POF3-553
|c POF3-553
|f POF III
|x 0
588 _ _ |a Dataset connected to CrossRef
700 1 _ |a Schwarten, Melanie
|0 P:(DE-Juel1)132019
|b 1
|u fzj
700 1 _ |a Hoffmann, Silke
|0 P:(DE-Juel1)132003
|b 2
|u fzj
700 1 _ |a Willbold, Dieter
|0 P:(DE-Juel1)132029
|b 3
|u fzj
700 1 _ |a Sklan, Ella
|0 P:(DE-HGF)0
|b 4
700 1 _ |a König, Bernd
|0 P:(DE-Juel1)132009
|b 5
|e Corresponding author
|u fzj
773 _ _ |a 10.3390/v7072812
|g Vol. 7, no. 7, p. 4119 - 4130
|0 PERI:(DE-600)2516098-9
|n 7
|p 4119 - 4130
|t Viruses
|v 7
|y 2015
|x 1999-4915
856 4 _ |y OpenAccess
|u https://juser.fz-juelich.de/record/276643/files/Amino%20Terminal%20Region%20of%20Dengue%20Virus%20NS4A%20Cytosolic%20Domain%20Binds%20to%20Highly%20Curved%20Liposomes.pdf
856 4 _ |y OpenAccess
|x icon
|u https://juser.fz-juelich.de/record/276643/files/Amino%20Terminal%20Region%20of%20Dengue%20Virus%20NS4A%20Cytosolic%20Domain%20Binds%20to%20Highly%20Curved%20Liposomes.gif?subformat=icon
856 4 _ |y OpenAccess
|x icon-1440
|u https://juser.fz-juelich.de/record/276643/files/Amino%20Terminal%20Region%20of%20Dengue%20Virus%20NS4A%20Cytosolic%20Domain%20Binds%20to%20Highly%20Curved%20Liposomes.jpg?subformat=icon-1440
856 4 _ |y OpenAccess
|x icon-180
|u https://juser.fz-juelich.de/record/276643/files/Amino%20Terminal%20Region%20of%20Dengue%20Virus%20NS4A%20Cytosolic%20Domain%20Binds%20to%20Highly%20Curved%20Liposomes.jpg?subformat=icon-180
856 4 _ |y OpenAccess
|x icon-640
|u https://juser.fz-juelich.de/record/276643/files/Amino%20Terminal%20Region%20of%20Dengue%20Virus%20NS4A%20Cytosolic%20Domain%20Binds%20to%20Highly%20Curved%20Liposomes.jpg?subformat=icon-640
856 4 _ |y OpenAccess
|x pdfa
|u https://juser.fz-juelich.de/record/276643/files/Amino%20Terminal%20Region%20of%20Dengue%20Virus%20NS4A%20Cytosolic%20Domain%20Binds%20to%20Highly%20Curved%20Liposomes.pdf?subformat=pdfa
909 C O |o oai:juser.fz-juelich.de:276643
|p openaire
|p open_access
|p OpenAPC
|p driver
|p VDB
|p openCost
|p dnbdelivery
910 1 _ |a Forschungszentrum Jülich GmbH
|0 I:(DE-588b)5008462-8
|k FZJ
|b 1
|6 P:(DE-Juel1)132019
910 1 _ |a Forschungszentrum Jülich GmbH
|0 I:(DE-588b)5008462-8
|k FZJ
|b 2
|6 P:(DE-Juel1)132003
910 1 _ |a Forschungszentrum Jülich GmbH
|0 I:(DE-588b)5008462-8
|k FZJ
|b 3
|6 P:(DE-Juel1)132029
910 1 _ |a Forschungszentrum Jülich GmbH
|0 I:(DE-588b)5008462-8
|k FZJ
|b 5
|6 P:(DE-Juel1)132009
913 1 _ |a DE-HGF
|b Key Technologies
|l BioSoft – Fundamentals for future Technologies in the fields of Soft Matter and Life Sciences
|1 G:(DE-HGF)POF3-550
|0 G:(DE-HGF)POF3-553
|2 G:(DE-HGF)POF3-500
|v Physical Basis of Diseases
|x 0
|4 G:(DE-HGF)POF
|3 G:(DE-HGF)POF3
914 1 _ |y 2015
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0200
|2 StatID
|b SCOPUS
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0300
|2 StatID
|b Medline
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)1050
|2 StatID
|b BIOSIS Previews
915 _ _ |a Creative Commons Attribution CC BY 4.0
|0 LIC:(DE-HGF)CCBY4
|2 HGFVOC
915 _ _ |a JCR
|0 StatID:(DE-HGF)0100
|2 StatID
|b VIRUSES-BASEL : 2014
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0150
|2 StatID
|b Web of Science Core Collection
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0500
|2 StatID
|b DOAJ
915 _ _ |a IF < 5
|0 StatID:(DE-HGF)9900
|2 StatID
915 _ _ |a OpenAccess
|0 StatID:(DE-HGF)0510
|2 StatID
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0310
|2 StatID
|b NCBI Molecular Biology Database
915 _ _ |a WoS
|0 StatID:(DE-HGF)0111
|2 StatID
|b Science Citation Index Expanded
915 _ _ |a DBCoverage
|0 StatID:(DE-HGF)0199
|2 StatID
|b Thomson Reuters Master Journal List
920 _ _ |l yes
920 1 _ |0 I:(DE-Juel1)ICS-6-20110106
|k ICS-6
|l Strukturbiochemie
|x 0
980 1 _ |a UNRESTRICTED
980 1 _ |a FullTexts
980 _ _ |a journal
980 _ _ |a VDB
980 _ _ |a UNRESTRICTED
980 _ _ |a I:(DE-Juel1)ICS-6-20110106
980 _ _ |a APC
981 _ _ |a I:(DE-Juel1)IBI-7-20200312

LibraryCollectionCLSMajorCLSMinorLanguageAuthor
Marc 21