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000276647 1001_ $$0P:(DE-Juel1)132019$$aSchwarten, Melanie$$b0
000276647 245__ $$aNix directly binds to GABARAP: A possible crosstalk between apoptosis and autophagy
000276647 260__ $$aAbingdon, Oxon$$bTaylor & Francis$$c2009
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000276647 520__ $$aAutophagy, a pathway primarily relevant for cell survival, and apoptosis, a process invariably leading to cell death, are the two main mechanisms of cellular self-destruction, which are essential in cell growth, neurodegeneration, tumor suppression, stress and immune response. Currently, a potential crosstalk between apoptosis and autophagy is subject to intensive investigations since recently some direct junctions became obvious. The respective protein-protein interaction network, however, remains to be elucidated in detail. The γ-aminobutyric acid type A (GABAA) receptor-associated protein GABARAP belongs to a family of proteins implicated in intracellular transport events and was shown to be associated to autophagic processes. Using a phage display screening against the target protein GABARAP, we identified the proapoptotic protein Nix/Bnip3L to be a potential GABARAP ligand. In vitro binding studies, pull-down analysis,coimmunoprecipitation assays and colocalization studies confirmed a direct interaction of both proteins in mammalian cells.
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000276647 7001_ $$0P:(DE-Juel1)132012$$aMohrlüder, Jeannine$$b1
000276647 7001_ $$0P:(DE-Juel1)132033$$aMa, Peixiang$$b2
000276647 7001_ $$0P:(DE-Juel1)132023$$aStoldt, Matthias$$b3
000276647 7001_ $$0P:(DE-HGF)0$$aThielmann, Yvonne$$b4
000276647 7001_ $$0P:(DE-HGF)0$$aStangler, Thomas$$b5
000276647 7001_ $$0P:(DE-Juel1)128815$$aHersch, Nils$$b6$$ufzj
000276647 7001_ $$0P:(DE-Juel1)128817$$aHoffmann, Bernd$$b7
000276647 7001_ $$0P:(DE-Juel1)128833$$aMerkel, Rudolf$$b8
000276647 7001_ $$0P:(DE-Juel1)132029$$aWillbold, Dieter$$b9$$eCorresponding author
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