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| Hauptseite > Publikationsdatenbank > Nix directly binds to GABARAP: A possible crosstalk between apoptosis and autophagy > print |
| Hauptseite > Publikationsdatenbank > Nix directly binds to GABARAP: A possible crosstalk between apoptosis and autophagy > print |
| 001 | 276647 | ||
| 005 | 20210129220923.0 | ||
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| 082 | _ | _ | |a 570 |
| 100 | 1 | _ | |a Schwarten, Melanie |0 P:(DE-Juel1)132019 |b 0 |
| 245 | _ | _ | |a Nix directly binds to GABARAP: A possible crosstalk between apoptosis and autophagy |
| 260 | _ | _ | |a Abingdon, Oxon |c 2009 |b Taylor & Francis |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1449670061_32505 |2 PUB:(DE-HGF) |
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| 520 | _ | _ | |a Autophagy, a pathway primarily relevant for cell survival, and apoptosis, a process invariably leading to cell death, are the two main mechanisms of cellular self-destruction, which are essential in cell growth, neurodegeneration, tumor suppression, stress and immune response. Currently, a potential crosstalk between apoptosis and autophagy is subject to intensive investigations since recently some direct junctions became obvious. The respective protein-protein interaction network, however, remains to be elucidated in detail. The γ-aminobutyric acid type A (GABAA) receptor-associated protein GABARAP belongs to a family of proteins implicated in intracellular transport events and was shown to be associated to autophagic processes. Using a phage display screening against the target protein GABARAP, we identified the proapoptotic protein Nix/Bnip3L to be a potential GABARAP ligand. In vitro binding studies, pull-down analysis,coimmunoprecipitation assays and colocalization studies confirmed a direct interaction of both proteins in mammalian cells. |
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| 700 | 1 | _ | |a Mohrlüder, Jeannine |0 P:(DE-Juel1)132012 |b 1 |
| 700 | 1 | _ | |a Ma, Peixiang |0 P:(DE-Juel1)132033 |b 2 |
| 700 | 1 | _ | |a Stoldt, Matthias |0 P:(DE-Juel1)132023 |b 3 |
| 700 | 1 | _ | |a Thielmann, Yvonne |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Stangler, Thomas |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Hersch, Nils |0 P:(DE-Juel1)128815 |b 6 |u fzj |
| 700 | 1 | _ | |a Hoffmann, Bernd |0 P:(DE-Juel1)128817 |b 7 |
| 700 | 1 | _ | |a Merkel, Rudolf |0 P:(DE-Juel1)128833 |b 8 |
| 700 | 1 | _ | |a Willbold, Dieter |0 P:(DE-Juel1)132029 |b 9 |e Corresponding author |
| 773 | _ | _ | |a 10.4161/auto.5.5.8494 |g Vol. 5, no. 5, p. 690 - 698 |0 PERI:(DE-600)2262043-6 |n 5 |p 690 - 698 |t Autophagy |v 5 |y 2009 |x 1554-8635 |
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