TY - JOUR AU - Bulavin, L. A. AU - Soloviov, D. V. AU - Gordeliy, Valentin AU - Svechnikova, O. S. AU - Krasnikova, A. O. AU - Kasian, N. A. AU - Vashchenko, O. V. AU - Lisetski, L. N. TI - Lyotropic model membrane structures of hydrated DPPC: DSC and small-angle X-ray scattering studies of phase transitions in the presence of membranotropic agents JO - Phase transitions VL - 88 IS - 6 SN - 1029-0338 CY - London [u.a.] PB - Taylor & Francis M1 - FZJ-2015-07401 SP - 582 - 592 PY - 2015 AB - Multibilayer structures of hydrated phospholipids, often considered as model biological membranes, are, from the physical viewpoint, lyotropic liquid crystalline systems undergoing temperature-induced mesomorphic phase transitions. Effects of silver nitrate and urocanic acid on lyotropic phase states of hydrated L-α-dipalmitoylphosphatidylcholine (DPPC) have been studied by small-angle X-ray scattering and differential scanning calorimetry (DSC). Both methods show increase of the main phase-transition temperature (Tm) of hydrated DPPC upon introduction of AgNO3 or urocanic acid, decrease of pre-transition temperature (Tp) in the presence of urocanic acid and its increase in the presence of AgNO3. Thus, urocanic acid widened the ripple-phase temperature region. Silver nitrate caused the appearance of an additional high-temperature peak on DSC thermograms, evidencing phase separation in the system. Both agents caused minor effects on DPPC lipid bilayer repeat distance (D) in gel phase, but resulted in noticeable increase of D in the liquid crystal phase with temperature as compared to undoped DPPC structures. LB - PUB:(DE-HGF)16 UR - <Go to ISI:>//WOS:000354456900004 DO - DOI:10.1080/01411594.2014.1002784 UR - https://juser.fz-juelich.de/record/279389 ER -