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@ARTICLE{Zhang:279812,
author = {Zhang, Zunmin and Henry, Ewan and Gompper, Gerhard and
Fedosov, Dmitry},
title = {{B}ehavior of rigid and deformable particles in
deterministic lateral displacement devices with different
post shapes},
journal = {The journal of chemical physics},
volume = {143},
number = {24},
issn = {1089-7690},
address = {Melville, NY},
publisher = {American Institute of Physics},
reportid = {FZJ-2015-07691},
pages = {243145 -},
year = {2015},
abstract = {Deterministic lateral displacement (DLD) devices have great
potential for the separation and sorting of various
suspended particles based on their size, shape,
deformability, and other intrinsic properties. Currently,
the basic idea for the separation mechanism is that the
structure and geometry of DLDs uniquely determine the flow
field, which in turn defines a critical particle size and
the particle lateral displacement within a device. We employ
numerical simulations using coarse-grained mesoscopic
methods and two-dimensional models to elucidate the dynamics
of both rigid spherical particles and deformable red blood
cells (RBCs) in different DLD geometries. Several shapes of
pillars, including circular, diamond, square, and triangular
structures, and a few particle sizes are considered. The
simulation results show that a critical particle size can be
well defined for rigid spherical particles and depends on
the details of the DLD structure and the corresponding flow
field within the device. However, non-isotropic and
deformable particles such as RBCs exhibit much more complex
dynamics within a DLD device, which cannot properly be
described by a single parameter such as the critical size.
The dynamics and deformation of soft particles within a DLD
device become also important, indicating that not only size
sorting, but additional sorting targets (e.g., shape,
deformability, internal viscosity) are possible.},
cin = {IAS-2 / ICS-2},
ddc = {540},
cid = {I:(DE-Juel1)IAS-2-20090406 / I:(DE-Juel1)ICS-2-20110106},
pnm = {551 - Functional Macromolecules and Complexes (POF3-551)},
pid = {G:(DE-HGF)POF3-551},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000370412900051},
pubmed = {26723630},
doi = {10.1063/1.4937171},
url = {https://juser.fz-juelich.de/record/279812},
}