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@ARTICLE{Dufour:280153,
      author       = {Dufour, A. and Rollenhagen, A. and Sätzler, K. and Lübke,
                      Joachim},
      title        = {{D}evelopment of {S}ynaptic {B}outons in {L}ayer 4 of the
                      {B}arrel {F}ield of the {R}at {S}omatosensory {C}ortex: {A}
                      {Q}uantitative {A}nalysis},
      journal      = {Cerebral cortex},
      volume       = {26},
      number       = {2},
      issn         = {1460-2199},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2015-07899},
      pages        = {838-854},
      year         = {2016},
      abstract     = {Understanding the structural and functional mechanisms
                      underlying the development of individual brain microcircuits
                      is critical for elucidating their computational properties.
                      As synapses are the key structures defining a given
                      microcircuit, it is imperative to investigate their
                      development and precise structural features. Here, synapses
                      in cortical layer 4 were analyzed throughout the first
                      postnatal month using high-end electron microscopy to
                      generate realistic quantitative 3D models. Besides their
                      overall geometry, the size of active zones and the pools of
                      synaptic vesicles were analyzed. At postnatal day 2 only a
                      few shaft synapses were found, but spine synapses steadily
                      increased with ongoing corticogenesis. From postnatal day 2
                      to 30 synaptic boutons significantly decreased in size
                      whereas that of active zones remained nearly unchanged
                      despite a reshaping. During the first 2 weeks of postnatal
                      development, a rearrangement of synaptic vesicles from a
                      loose distribution toward a densely packed organization
                      close to the presynaptic density was observed, accompanied
                      by the formation of, first a putative readily releasable
                      pool and later a recycling and reserve pool. The
                      quantitative 3D reconstructions of synapses will enable the
                      comparison of structural and functional aspects of signal
                      transduction thus leading to a better understanding of
                      networks in the developing neocortex.},
      cin          = {INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-2-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571)},
      pid          = {G:(DE-HGF)POF3-571},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000371522500031},
      pubmed       = {pmid:26574502},
      doi          = {10.1093/cercor/bhv270},
      url          = {https://juser.fz-juelich.de/record/280153},
}