% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Schmidt:280378,
      author       = {Schmidt, Daniel and Bihr, Timo and Fenz, Susanne and
                      Merkel, Rudolf and Seifert, Udo and Sengupta, Kheya and
                      Smith, Ana-Sunčana},
      title        = {{C}rowding of receptors induces ring-like adhesions in
                      model membranes},
      journal      = {Biochimica et biophysica acta / Molecular cell research},
      volume       = {1853},
      number       = {11},
      issn         = {0167-4889},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2016-00155},
      pages        = {2984 - 2991},
      year         = {2015},
      abstract     = {The dynamics of formation of macromolecular structures in
                      adherent membranes is a key to a number of cellular
                      processes. However, the interplay between protein reaction
                      kinetics, diffusion and the morphology of the growing
                      domains, governed by membrane mediated interactions, is
                      still poorly understood. Here we show, experimentally and in
                      simulations, that a rich phase diagram emerges from the
                      competition between binding, cooperativity, molecular
                      crowding and membrane spreading. In the cellular context,
                      the spontaneously-occurring organization of adhesion domains
                      in ring-like morphologies is particularly interesting. These
                      are stabilized by the crowding of bulky proteins, and the
                      membrane-transmitted correlations between bonds. Depending
                      on the density of the receptors, this phase may be
                      circumvented, and instead, the adhesions may grow
                      homogeneously in the contact zone between two membranes. If
                      the development of adhesion occurs simultaneously with
                      membrane spreading, much higher accumulation of binders can
                      be achieved depending on the velocity of spreading. The
                      mechanisms identified here, in the context of our mimetic
                      model, may shed light on the structuring of adhesions in the
                      contact zones between two living cells. This article is part
                      of a Special Issue entitled: Mechanobiology.},
      cin          = {ICS-7},
      ddc          = {570},
      cid          = {I:(DE-Juel1)ICS-7-20110106},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000363069200003},
      doi          = {10.1016/j.bbamcr.2015.05.025},
      url          = {https://juser.fz-juelich.de/record/280378},
}