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@ARTICLE{Mathys:280396,
      author       = {Mathys, Christian and Caspers, Julian and Langner, Robert
                      and Südmeyer, Martin and Grefkes, Christian and Reetz,
                      Kathrin and Moldovan, Alexia-Sabine and Michely, Jochen and
                      Heller, Julia and Eickhoff, Claudia R and Turowski, Bernd
                      and Schnitzler, Alfons and Hoffstaedter, Felix and Eickhoff,
                      Simon},
      title        = {{F}unctional {C}onnectivity {D}ifferences of the
                      {S}ubthalamic {N}ucleus {R}elated to {P}arkinson's
                      {D}isease.},
      journal      = {Human brain mapping},
      volume       = {37},
      number       = {3},
      issn         = {1065-9471},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {FZJ-2016-00173},
      pages        = {1235-1253},
      year         = {2016},
      abstract     = {A typical feature of Parkinson's disease (PD) is
                      pathological activity in the subthalamic nucleus (STN).
                      Here, we tested whether in patients with PD under
                      dopaminergic treatment functional connectivity of the STN
                      differs from healthy controls (HC) and whether some brain
                      regions show (anti-) correlations between functional
                      connectivity with STN and motor symptoms. We used functional
                      magnetic resonance imaging to investigate whole-brain
                      resting-state functional connectivity with STN in 54
                      patients with PD and 55 HC matched for age, gender, and
                      within-scanner motion. Compared to HC, we found attenuated
                      negative STN-coupling with Crus I of the right cerebellum
                      and with right ventromedial prefrontal regions in patients
                      with PD. Furthermore, we observed enhanced negative
                      STN-coupling with bilateral intraparietal sulcus/superior
                      parietal cortex, right sensorimotor, right premotor, and
                      left visual cortex compared to HC. Finally, we found a
                      decline in positive STN-coupling with the left insula
                      related to severity of motor symptoms and a decline of
                      inter-hemispheric functional connectivity between left and
                      right STN with progression of PD-related motor symptoms.
                      Motor symptom related uncoupling of the insula, a key region
                      in the saliency network and for executive function, from the
                      STN might be associated with well-known executive
                      dysfunction in PD. Moreover, uncoupling between insula and
                      STN might also induce an insufficient setting of thresholds
                      for the discrimination between relevant and irrelevant
                      salient environmental stimuli, explaining observations of
                      disturbed response control in PD. In sum, motor symptoms in
                      PD are associated with a reduced coupling between STN and a
                      key region for executive function. Hum Brain Mapp, 2015. ©
                      2015 Wiley Periodicals, Inc.},
      cin          = {INM-1 / JARA-BRAIN / INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406 / $I:(DE-82)080010_20140620$ /
                      I:(DE-Juel1)INM-3-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571) / HBP - The
                      Human Brain Project (604102)},
      pid          = {G:(DE-HGF)POF3-571 / G:(EU-Grant)604102},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:26700444},
      UT           = {WOS:000370243600029},
      doi          = {10.1002/hbm.23099},
      url          = {https://juser.fz-juelich.de/record/280396},
}