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@ARTICLE{Li:280466,
      author       = {Li, Jinyu and Santambrogio, Carlo and Brocca, Stefania and
                      Rossetti, Giulia and Carloni, Paolo and Grandori, Rita},
      title        = {{C}onformational effects in protein electrospray-ionization
                      mass spectrometry},
      journal      = {Mass spectrometry reviews},
      volume       = {35},
      number       = {1},
      issn         = {0277-7037},
      address      = {New York, NY [u.a.]},
      publisher    = {Wiley},
      reportid     = {FZJ-2016-00240},
      pages        = {111 - 122},
      year         = {2016},
      abstract     = {Electrospray-ionization mass spectrometry (ESI-MS) is a key
                      tool of structural biology, complementing the information
                      delivered by conventional biochemical and biophysical
                      methods. Yet, the mechanism behind the conformational
                      effects in protein ESI-MS is an object of debate. Two
                      parameters—solvent-accessible surface area (As) and
                      apparent gas-phase basicity (GBapp)—are thought to play a
                      role in controlling the extent of protein ionization during
                      ESI-MS experiments. This review focuses on recent
                      experimental and theoretical investigations concerning the
                      influence of these parameters on ESI-MS results and the
                      structural information that can be derived. The available
                      evidence supports a unified model for the ionization
                      mechanism of folded and unfolded proteins. These data
                      indicate that charge-state distribution (CSD) analysis can
                      provide valuable structural information on normally folded,
                      as well as disordered structures.},
      cin          = {JSC / INM-9 / IAS-5 / GRS Jülich ; German Research School
                      for Simulation Sciences},
      ddc          = {530},
      cid          = {I:(DE-Juel1)JSC-20090406 / I:(DE-Juel1)INM-9-20140121 /
                      I:(DE-Juel1)IAS-5-20120330 / I:(DE-Juel1)GRS-20100316},
      pnm          = {511 - Computational Science and Mathematical Methods
                      (POF3-511) / 574 - Theory, modelling and simulation
                      (POF3-574)},
      pid          = {G:(DE-HGF)POF3-511 / G:(DE-HGF)POF3-574},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000368739100007},
      pubmed       = {pmid:25952139},
      doi          = {10.1002/mas.21465},
      url          = {https://juser.fz-juelich.de/record/280466},
}