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@ARTICLE{Pluhackova:280756,
author = {Pluhackova, Kristyna and Morhenn, Humphrey and Lautner,
Lisa and Lohstroh, Wiebke and Nemkovskiy, Kirill and Unruh,
Tobias and Böckmann, Rainer A.},
title = {{E}xtension of the {LOPLS}-{AA} {F}orce {F}ield for
{A}lcohols, {E}sters, and {M}onoolein {B}ilayers and its
{V}alidation by {N}eutron {S}cattering {E}xperiments},
journal = {The journal of physical chemistry / B},
volume = {119},
number = {49},
issn = {1520-5207},
address = {Washington, DC},
publisher = {Soc.},
reportid = {FZJ-2016-00513},
pages = {15287 - 15299},
year = {2015},
abstract = {The recently presented LOPLS-AA all-atom force field for
long hydrocarbon chains, based on the OPLS-AA force field,
was extended to alcohols, esters, and glyceryl monooleate
(GMO) lipids as a model lipid. Dihedral angles were fitted
against high level ab initio calculations, and ester charges
were increased to improve their hydration properties.
Additionally, the ester Lennard-Jones parameters were
readjusted to reproduce experimental liquid bulk properties,
densities, and heats of vaporization. This extension enabled
the setup of LOPLS-AA parameters for GMO molecules. The
properties of the lipid force field were tested for the
liquid-crystalline phase of a GMO bilayer. The obtained area
per lipid for GMO is in good agreement with experiment.
Additionally, the lipid dynamics on the subpicosecond to the
nanosecond time scale is in excellent agreement with results
from time-of-flight (TOF) quasielastic neutron scattering
(QENS) experiments on a multilamellar monoolein system,
enabling here for the first time the critical evaluation of
the short-time dynamics obtained from a molecular dynamics
simulation of a membrane system.},
cin = {JCNS (München) ; Jülich Centre for Neutron Science JCNS
(München) ; JCNS-FRM-II / JCNS-2},
ddc = {530},
cid = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
I:(DE-Juel1)JCNS-2-20110106},
pnm = {6G15 - FRM II / MLZ (POF3-6G15) / 6G4 - Jülich Centre for
Neutron Research (JCNS) (POF3-623)},
pid = {G:(DE-HGF)POF3-6G15 / G:(DE-HGF)POF3-6G4},
experiment = {EXP:(DE-MLZ)TOF-TOF-20140101 / EXP:(DE-MLZ)DNS-20140101},
typ = {PUB:(DE-HGF)16},
UT = {WOS:000366339700020},
doi = {10.1021/acs.jpcb.5b08569},
url = {https://juser.fz-juelich.de/record/280756},
}