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000280772 1001_ $$0P:(DE-Juel1)145322$$aMichel, Max$$b0
000280772 245__ $$aThe mammalian autophagy initiator complex contains 2 HORMA domain proteins.
000280772 260__ $$aAbingdon, Oxon$$bTaylor & Francis$$c2015
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000280772 520__ $$aATG101 is an essential component of the ULK complex responsible for initiating cellular autophagy in mammalian cells; its 3-dimensional structure and molecular function, however, are currently unclear. Here we present the X-ray structure of human ATG101. The protein displays an open HORMA domain fold. Both structural properties and biophysical evidence indicate that ATG101 is locked in this conformation, in contrast to the prototypical HORMA domain protein MAD2. Moreover, we discuss a potential mode of dimerization with ATG13 as a fundamental aspect of ATG101 function.
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000280772 7001_ $$0P:(DE-Juel1)132019$$aSchwarten, Melanie$$b1$$ufzj
000280772 7001_ $$0P:(DE-Juel1)162438$$aDecker, Christina$$b2
000280772 7001_ $$0P:(DE-Juel1)162443$$aNagel-Steger, Luitgard$$b3$$ufzj
000280772 7001_ $$0P:(DE-Juel1)132029$$aWillbold, Dieter$$b4$$ufzj
000280772 7001_ $$0P:(DE-Juel1)131988$$aWeiergräber, Oliver H.$$b5$$eCorresponding author$$ufzj
000280772 773__ $$0PERI:(DE-600)2262043-6$$a10.1080/15548627.2015.1076605$$gVol. 11, no. 12, p. 2300 - 2308$$n12$$p2300 - 2308$$tAutophagy$$v11$$x1554-8635$$y2015
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