TY  - JOUR
AU  - Joset, Arnaud
AU  - Grammenos, Angeliki
AU  - Hoebeke, Maryse
AU  - Leyh, Bernard
TI  - Investigation of the interaction between a β-cyclodextrin and DMPC liposomes: a small angle neutron scattering study
JO  - Journal of inclusion phenomena and macrocyclic chemistry
VL  - 83
IS  - 3
SN  - 1573-1111
CY  - Dordrecht [u.a.]
PB  - Springer Science + Business Media B.V
M1  - FZJ-2016-00542
SP  - 227 - 238
PY  - 2015
N1  - no Final Draft Post Referee available
AB  - The small angle neutron scattering technique has been applied to investigate the interaction between a cyclodextrin (CD) and liposomes. From the modelling of the experimental neutron scattering cross sections, the detailed structure of dimyristoylphosphatidylcholine (DMPC) liposomes is assessed upon addition of increasing amounts of randomly methylated β-CD (RAMEB). This study has been performed at two temperatures bracketing the phase transition of the DMPC bilayers. The fraction of DMPC molecules incorporated into the vesicles is inferred. The dose-dependent phospholipidic extraction by RAMEB is quantified as well as the concomitant evolution of the liposome radius and of the thickness of the hydrophobic and hydrophilic parts of the membrane. The possible formation of CD-DMPC inclusion complexes is also assessed. The data suggest the dose-dependent coverage by RAMEB of the outer liposome interface. Our analysis highlights the important role of temperature on the mechanism of action of RAMEB. These results are discussed in the framework of the area-difference-elasticity model.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000364225300003
DO  - DOI:10.1007/s10847-015-0558-z
UR  - https://juser.fz-juelich.de/record/280821
ER  -