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@ARTICLE{Garcia:281437,
      author       = {Garcia, Simon and Hannezo, Edouard and Elgeti, Jens and
                      Joanny, Jean-Francois and Silberzan, Pascal and Gov, Nir S.},
      title        = {{P}hysics of active jamming during collective cellular
                      motion in a monolayer},
      journal      = {Proceedings of the National Academy of Sciences of the
                      United States of America},
      volume       = {112},
      issn         = {0027-8424},
      address      = {Washington, DC},
      publisher    = {National Acad. of Sciences},
      reportid     = {FZJ-2016-01130},
      pages        = {15314-15319},
      year         = {2015},
      abstract     = {Although collective cell motion plays an important role,
                      for example during wound healing, embryogenesis, or cancer
                      progression, the fundamental rules governing this motion are
                      still not well understood, in particular at high cell
                      density. We study here the motion of human bronchial
                      epithelial cells within a monolayer, over long times. We
                      observe that, as the monolayer ages, the cells slow down
                      monotonously, while the velocity correlation length first
                      increases as the cells slow down but eventually decreases at
                      the slowest motions. By comparing experiments, analytic
                      model, and detailed particle-based simulations, we shed
                      light on this biological amorphous solidification process,
                      demonstrating that the observed dynamics can be explained as
                      a consequence of the combined maturation and strengthening
                      of cell-cell and cell-substrate adhesions. Surprisingly, the
                      increase of cell surface density due to proliferation is
                      only secondary in this process. This analysis is confirmed
                      with two other cell types. The very general relations
                      between the mean cell velocity and velocity correlation
                      lengths, which apply for aggregates of self-propelled
                      particles, as well as motile cells, can possibly be used to
                      discriminate between various parameter changes in vivo, from
                      noninvasive microscopy data.},
      cin          = {IAS-2 / ICS-2},
      ddc          = {000},
      cid          = {I:(DE-Juel1)IAS-2-20090406 / I:(DE-Juel1)ICS-2-20110106},
      pnm          = {553 - Physical Basis of Diseases (POF3-553)},
      pid          = {G:(DE-HGF)POF3-553},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000366404200043},
      pubmed       = {pmid:26627719},
      doi          = {10.1073/pnas.1510973112},
      url          = {https://juser.fz-juelich.de/record/281437},
}