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@ARTICLE{Hauptmann:281677,
      author       = {Hauptmann, Christian and Ströbel, Armin and Williams, Mark
                      and Patel, Nitesh and Wurzer, Hannes and von Stackelberg,
                      Tatjana and Brinkmann, Uwe and Langguth, Berthold and Tass,
                      Peter A.},
      title        = {{A}coustic {C}oordinated {R}eset {N}euromodulation in a
                      {R}eal {L}ife {P}atient {P}opulation with {C}hronic {T}onal
                      {T}innitus},
      journal      = {BioMed research international},
      volume       = {2015},
      issn         = {2314-6141},
      address      = {New York [u.a.]},
      publisher    = {Hindawi},
      reportid     = {FZJ-2016-01365},
      pages        = {569052},
      year         = {2015},
      abstract     = {Purpose. Primary tinnitus has a severe negative influence
                      on the quality of life of a significant portion of the
                      general population. Acoustic coordinated reset
                      neuromodulation is designed to induce a long-lasting
                      reduction of tinnitus symptoms. To test acoustic coordinated
                      reset neuromodulation as a treatment for chronic, tonal
                      tinnitus under real life conditions, an outpatient study
                      “RESET Real Life” was commissioned by ANM GmbH. Herein
                      we present the results of this study. Methods. In a
                      prospective, open-label, nonrandomized, noncontrolled
                      multicenter clinical study with 200 chronic tinnitus
                      patients, tinnitus questionnaire TBF-12 and Global Clinical
                      Improvement-Impression Scale (CGI-I7) are used to study the
                      safety and efficacy of acoustic coordinated reset
                      neuromodulation. 189 patients completed the last 12-month
                      visit, 11 patients dropped out (8 because of nontreatment
                      related reasons; 2 because tinnitus did not change; and 1
                      because tinnitus got louder). Results. Acoustic coordinated
                      reset neuromodulation caused a statistically and clinically
                      significant decrease in TBF-12 scores as well as in CGI-I7
                      after 12 months of therapy under real life conditions. There
                      were no persistent adverse events reported that were related
                      to the therapy. Conclusion. The field study “RESET Real
                      Life” provides evidence for safety and efficacy of
                      acoustic coordinated reset neuromodulation in a prospective,
                      open-label, real life setting.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {89572 - (Dys-)function and Plasticity (POF2-89572) /
                      BHG-FZJ - Zusammenarbeits- und Lizenzoptionsvereinbarung
                      zwischen Brook Henderson Group Limited und Forschungszentrum
                      Jülich GmbH $(BHG_T/Z4000.01.13_19022015)$},
      pid          = {G:(DE-HGF)POF2-89572 /
                      $G:(DE-Juel-1)BHG_T/Z4000.01.13_19022015$},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000364067900001},
      pubmed       = {pmid:26568958},
      doi          = {10.1155/2015/569052},
      url          = {https://juser.fz-juelich.de/record/281677},
}