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000281691 1001_ $$0P:(DE-Juel1)136723$$aZeitler, Magteld$$b0$$eCorresponding author$$ufzj
000281691 245__ $$aAugmented brain function by coordinated reset stimulation with slowly varying sequences
000281691 260__ $$aLausanne$$bFrontiers Research Foundation$$c2015
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000281691 520__ $$aSeveral brain disorders are characterized by abnormally strong neuronal synchrony. Coordinated Reset (CR) stimulation was developed to selectively counteract abnormal neuronal synchrony by desynchronization. For this, phase resetting stimuli are delivered to different subpopulations in a timely coordinated way. In neural networks with spike timing-dependent plasticity CR stimulation may eventually lead to an anti-kindling, i.e., an unlearning of abnormal synaptic connectivity and abnormal synchrony. The spatiotemporal sequence by which all stimulation sites are stimulated exactly once is called the stimulation site sequence, or briefly sequence. So far, in simulations, pre-clinical and clinical applications CR was applied either with fixed sequences or rapidly varying sequences (RVS). In this computational study we show that appropriate repetition of the sequence with occasional random switching to the next sequence may significantly improve the anti-kindling effect of CR. To this end, a sequence is applied many times before randomly switching to the next sequence. This new method is called SVS CR stimulation, i.e., CR with slowly varying sequences. In a neuronal network with strong short-range excitatory and weak long-range inhibitory dynamic couplings SVS CR stimulation turns out to be superior to CR stimulation with fixed sequences or RVS.
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000281691 7001_ $$0P:(DE-Juel1)131884$$aTass, Peter A.$$b1$$ufzj
000281691 773__ $$0PERI:(DE-600)2453005-0$$a10.3389/fnsys.2015.00049$$gVol. 9$$p49$$tFrontiers in systems neuroscience$$v9$$x1662-5137$$y2015
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