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@ARTICLE{Zeitler:281691,
      author       = {Zeitler, Magteld and Tass, Peter A.},
      title        = {{A}ugmented brain function by coordinated reset stimulation
                      with slowly varying sequences},
      journal      = {Frontiers in systems neuroscience},
      volume       = {9},
      issn         = {1662-5137},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {FZJ-2016-01379},
      pages        = {49},
      year         = {2015},
      abstract     = {Several brain disorders are characterized by abnormally
                      strong neuronal synchrony. Coordinated Reset (CR)
                      stimulation was developed to selectively counteract abnormal
                      neuronal synchrony by desynchronization. For this, phase
                      resetting stimuli are delivered to different subpopulations
                      in a timely coordinated way. In neural networks with spike
                      timing-dependent plasticity CR stimulation may eventually
                      lead to an anti-kindling, i.e., an unlearning of abnormal
                      synaptic connectivity and abnormal synchrony. The
                      spatiotemporal sequence by which all stimulation sites are
                      stimulated exactly once is called the stimulation site
                      sequence, or briefly sequence. So far, in simulations,
                      pre-clinical and clinical applications CR was applied either
                      with fixed sequences or rapidly varying sequences (RVS). In
                      this computational study we show that appropriate repetition
                      of the sequence with occasional random switching to the next
                      sequence may significantly improve the anti-kindling effect
                      of CR. To this end, a sequence is applied many times before
                      randomly switching to the next sequence. This new method is
                      called SVS CR stimulation, i.e., CR with slowly varying
                      sequences. In a neuronal network with strong short-range
                      excitatory and weak long-range inhibitory dynamic couplings
                      SVS CR stimulation turns out to be superior to CR
                      stimulation with fixed sequences or RVS.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {89572 - (Dys-)function and Plasticity (POF2-89572)},
      pid          = {G:(DE-HGF)POF2-89572},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000363676700001},
      pubmed       = {pmid:25873867},
      doi          = {10.3389/fnsys.2015.00049},
      url          = {https://juser.fz-juelich.de/record/281691},
}