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000281720 1001_ $$0P:(DE-HGF)0$$aSebastiani, F.$$b0
000281720 245__ $$aHydration-dependent dynamics of human telomeric oligonucleotides in the picosecond timescale: A neutron scattering study
000281720 260__ $$aMelville, NY$$bAmerican Institute of Physics$$c2015
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000281720 520__ $$aThe dynamics of the human oligonucleotide AG 3(T2 AG 3)3 has been investigated by incoherent neutron scattering in the sub-nanosecond timescale. A hydration-dependent dynamical activation of thermal fluctuations in weakly hydrated samples was found, similar to that of protein powders. The amplitudes of such thermal fluctuations were evaluated in two different exchanged wave-vector ranges, so as to single out the different contributions from intra- and inter-nucleotide dynamics. The activation energy was calculated from the temperature-dependent characteristic times of the corresponding dynamical processes. The trends of both amplitudes and activation energies support a picture where oligonucleotides possess a larger conformational flexibility than long DNA sequences. This additional flexibility, which likely results from a significant relative chain-end contribution to the average chain dynamics, could be related to the strong structural polymorphism of the investigated oligonucleotides.
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000281720 7001_ $$0P:(DE-HGF)0$$aLongo, M.$$b1
000281720 7001_ $$0P:(DE-HGF)0$$aOrecchini, A.$$b2
000281720 7001_ $$0P:(DE-HGF)0$$aComez, L.$$b3
000281720 7001_ $$0P:(DE-HGF)0$$aDe Francesco, A.$$b4
000281720 7001_ $$0P:(DE-Juel1)140457$$aMuthmann, M.$$b5
000281720 7001_ $$00000-0002-1967-0026$$aTeixeira, S. C. M.$$b6
000281720 7001_ $$0P:(DE-HGF)0$$aPetrillo, C.$$b7
000281720 7001_ $$0P:(DE-HGF)0$$aSacchetti, F.$$b8
000281720 7001_ $$0P:(DE-HGF)0$$aPaciaroni, A.$$b9$$eCorresponding author
000281720 773__ $$0PERI:(DE-600)1473050-9$$a10.1063/1.4923213$$gVol. 143, no. 1, p. 015102 -$$n1$$p015102 -$$tThe journal of chemical physics$$v143$$x1089-7690$$y2015
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