TY  - JOUR
AU  - Sebastiani, F.
AU  - Longo, M.
AU  - Orecchini, A.
AU  - Comez, L.
AU  - De Francesco, A.
AU  - Muthmann, M.
AU  - Teixeira, S. C. M.
AU  - Petrillo, C.
AU  - Sacchetti, F.
AU  - Paciaroni, A.
TI  - Hydration-dependent dynamics of human telomeric oligonucleotides in the picosecond timescale: A neutron scattering study
JO  - The journal of chemical physics
VL  - 143
IS  - 1
SN  - 1089-7690
CY  - Melville, NY
PB  - American Institute of Physics
M1  - FZJ-2016-01408
SP  - 015102 -
PY  - 2015
N1  - "final draft post referee" can nicht beigebracht werden
AB  - The dynamics of the human oligonucleotide AG 3(T2 AG 3)3 has been investigated by incoherent neutron scattering in the sub-nanosecond timescale. A hydration-dependent dynamical activation of thermal fluctuations in weakly hydrated samples was found, similar to that of protein powders. The amplitudes of such thermal fluctuations were evaluated in two different exchanged wave-vector ranges, so as to single out the different contributions from intra- and inter-nucleotide dynamics. The activation energy was calculated from the temperature-dependent characteristic times of the corresponding dynamical processes. The trends of both amplitudes and activation energies support a picture where oligonucleotides possess a larger conformational flexibility than long DNA sequences. This additional flexibility, which likely results from a significant relative chain-end contribution to the average chain dynamics, could be related to the strong structural polymorphism of the investigated oligonucleotides.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000357873900039
C6  - pmid:26156493
DO  - DOI:10.1063/1.4923213
UR  - https://juser.fz-juelich.de/record/281720
ER  -