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@ARTICLE{Mller:281788,
      author       = {Müller, Kathrin and Fedosov, Dmitry and Gompper, Gerhard},
      title        = {{U}nderstanding particle margination in blood flow - {A}
                      step toward optimized drug delivery systems},
      journal      = {Medical engineering $\&$ physics},
      volume       = {38},
      number       = {1},
      issn         = {1350-4533},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2016-01457},
      pages        = {2-10},
      year         = {2016},
      abstract     = {Targeted delivery of drugs and imaging agents is very
                      promising to develop new strategies for the treatment of
                      various diseases such as cancer. For an efficient targeted
                      adhesion, the particles have to migrate toward the walls in
                      blood flow - a process referred to as margination. Due to a
                      huge diversity of available carriers, a good understanding
                      of their margination properties in blood flow depending on
                      various flow conditions and particle properties is required.
                      We employ a particle-based mesoscopic hydrodynamic
                      simulation approach to investigate the margination of
                      different carriers for a wide range of hematocrits (volume
                      fraction of red blood cells) and flow rates. Our results
                      show that margination strongly depends on the thickness of
                      the available free space close to the wall, the so-called
                      red blood cell-free layer (RBC-FL), in comparison to the
                      carrier size. The carriers with a few micrometers in size
                      are comparable with the RBC-FL thickness and marginate
                      better than their sub-micrometer counterparts. Deformable
                      carriers, in general, show worse margination properties than
                      rigid particles. Particle margination is also found to be
                      most pronounced in small channels with a characteristic size
                      comparable to blood capillaries. Finally, different
                      margination mechanisms are discussed.},
      cin          = {IAS-2 / ICS-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)IAS-2-20090406 / I:(DE-Juel1)ICS-2-20110106},
      pnm          = {553 - Physical Basis of Diseases (POF3-553)},
      pid          = {G:(DE-HGF)POF3-553},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000370770800002},
      pubmed       = {pmid:26343228},
      doi          = {10.1016/j.medengphy.2015.08.009},
      url          = {https://juser.fz-juelich.de/record/281788},
}