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@ARTICLE{Khoshakhlagh:281842,
      author       = {Khoshakhlagh, Pooneh and Johnson, Raphael and Langguth,
                      Peter and Nawroth, Thomas and Schmueser, Lars and Hellmann,
                      Nadja and Decker, Heinz and Szekely, Noemi},
      title        = {{F}asted-{S}tate {S}imulated {I}ntestinal {F}luid
                      '{F}a{SSIF}-{C}', a {C}holesterol {C}ontaining {I}ntestinal
                      {M}odel {M}edium for {I}n {V}itro {D}rug {D}elivery
                      {D}evelopment},
      journal      = {Journal of pharmaceutical sciences},
      volume       = {104},
      number       = {7},
      issn         = {0022-3549},
      address      = {New York, NY},
      publisher    = {Wiley},
      reportid     = {FZJ-2016-01509},
      pages        = {2213 - 2224},
      year         = {2015},
      abstract     = {A set of biorelevant media "fasted-state simulated
                      intestinal fluid with cholesterol (FaSSIF-C)" for the in
                      vitro study of intestinal drug dissolution in the duodenum
                      was developed. These contain cholesterol at the same levels
                      as in human bile: the cholesterol content of FaSSIF-7C is
                      equivalent to healthy female, FaSSIF-10C to healthy male
                      persons, and FaSSIF-13C to several disease cases that lead
                      to gallstones. The fluids were studied in three aspects:
                      biocompatibility, intestinal nanostructure, and solubilizing
                      power of hydrophobic drugs of the BCS class II. The
                      biocompatibility study showed no toxic effects in a Caco-2
                      cell system. The drug-solubilizing capacity toward
                      Fenofibrate, Danazol, Griseofulvin, and Carbamazepine was
                      assessed as example. It varied with the cholesterol content
                      widely from a fourfold improvement to a twofold reduction.
                      The nanostructure study by dynamic light scattering and
                      small-angle neutron scattering indicated vesicles as the
                      main component of FaSSIF-C in equilibrium (> 1 h), but at
                      high cholesterol content, larger particles were observed as
                      a minor contribution. The neutron experiments indicated the
                      presence of complex micelle-vesicle mixtures, even after 1 h
                      development of fed-state bile model to FaSSIF. The results
                      indicate that cholesterol affects some drugs in
                      solubilization and particle size in intestinal model
                      fluids.},
      cin          = {JCNS (München) ; Jülich Centre for Neutron Science JCNS
                      (München) ; JCNS-FRM-II / Neutronenstreuung ; JCNS-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106},
      pnm          = {6G15 - FRM II / MLZ (POF3-6G15) / 6G4 - Jülich Centre for
                      Neutron Research (JCNS) (POF3-623)},
      pid          = {G:(DE-HGF)POF3-6G15 / G:(DE-HGF)POF3-6G4},
      experiment   = {EXP:(DE-MLZ)KWS2-20140101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000356705500012},
      pubmed       = {pmid:25964103},
      doi          = {10.1002/jps.24470},
      url          = {https://juser.fz-juelich.de/record/281842},
}