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| 001 | 281842 | ||
| 005 | 20240619091203.0 | ||
| 024 | 7 | _ | |a 10.1002/jps.24470 |2 doi |
| 024 | 7 | _ | |a 0022-3549 |2 ISSN |
| 024 | 7 | _ | |a 1520-6017 |2 ISSN |
| 024 | 7 | _ | |a WOS:000356705500012 |2 WOS |
| 024 | 7 | _ | |a altmetric:4993849 |2 altmetric |
| 024 | 7 | _ | |a pmid:25964103 |2 pmid |
| 037 | _ | _ | |a FZJ-2016-01509 |
| 082 | _ | _ | |a 610 |
| 100 | 1 | _ | |a Khoshakhlagh, Pooneh |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a Fasted-State Simulated Intestinal Fluid 'FaSSIF-C', a Cholesterol Containing Intestinal Model Medium for In Vitro Drug Delivery Development |
| 260 | _ | _ | |a New York, NY |c 2015 |b Wiley |
| 336 | 7 | _ | |a article |2 DRIVER |
| 336 | 7 | _ | |a Output Types/Journal article |2 DataCite |
| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1478619010_18232 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a JOURNAL_ARTICLE |2 ORCID |
| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a A set of biorelevant media "fasted-state simulated intestinal fluid with cholesterol (FaSSIF-C)" for the in vitro study of intestinal drug dissolution in the duodenum was developed. These contain cholesterol at the same levels as in human bile: the cholesterol content of FaSSIF-7C is equivalent to healthy female, FaSSIF-10C to healthy male persons, and FaSSIF-13C to several disease cases that lead to gallstones. The fluids were studied in three aspects: biocompatibility, intestinal nanostructure, and solubilizing power of hydrophobic drugs of the BCS class II. The biocompatibility study showed no toxic effects in a Caco-2 cell system. The drug-solubilizing capacity toward Fenofibrate, Danazol, Griseofulvin, and Carbamazepine was assessed as example. It varied with the cholesterol content widely from a fourfold improvement to a twofold reduction. The nanostructure study by dynamic light scattering and small-angle neutron scattering indicated vesicles as the main component of FaSSIF-C in equilibrium (> 1 h), but at high cholesterol content, larger particles were observed as a minor contribution. The neutron experiments indicated the presence of complex micelle-vesicle mixtures, even after 1 h development of fed-state bile model to FaSSIF. The results indicate that cholesterol affects some drugs in solubilization and particle size in intestinal model fluids. |
| 536 | _ | _ | |0 G:(DE-HGF)POF3-6G15 |f POF III |x 0 |c POF3-6G15 |a 6G15 - FRM II / MLZ (POF3-6G15) |
| 536 | _ | _ | |a 6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623) |0 G:(DE-HGF)POF3-6G4 |c POF3-623 |f POF III |x 1 |
| 588 | _ | _ | |a Dataset connected to CrossRef |
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| 693 | _ | _ | |a Forschungs-Neutronenquelle Heinz Maier-Leibnitz |e KWS-2: Small angle scattering diffractometer |f NL3ao |1 EXP:(DE-MLZ)FRMII-20140101 |0 EXP:(DE-MLZ)KWS2-20140101 |5 EXP:(DE-MLZ)KWS2-20140101 |6 EXP:(DE-MLZ)NL3ao-20140101 |x 0 |
| 700 | 1 | _ | |a Johnson, Raphael |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Langguth, Peter |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Nawroth, Thomas |0 P:(DE-HGF)0 |b 3 |e Corresponding author |
| 700 | 1 | _ | |a Schmueser, Lars |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Hellmann, Nadja |0 P:(DE-HGF)0 |b 5 |
| 700 | 1 | _ | |a Decker, Heinz |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Szekely, Noemi |0 P:(DE-Juel1)145431 |b 7 |
| 773 | _ | _ | |a 10.1002/jps.24470 |g Vol. 104, no. 7, p. 2213 - 2224 |0 PERI:(DE-600)1491821-3 |n 7 |p 2213 - 2224 |t Journal of pharmaceutical sciences |v 104 |y 2015 |x 0022-3549 |
| 909 | C | O | |o oai:juser.fz-juelich.de:281842 |p VDB:MLZ |p VDB |
| 910 | 1 | _ | |a Forschungszentrum Jülich GmbH |0 I:(DE-588b)5008462-8 |k FZJ |b 7 |6 P:(DE-Juel1)145431 |
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| 913 | 1 | _ | |a DE-HGF |b Forschungsbereich Materie |l Von Materie zu Materialien und Leben |1 G:(DE-HGF)POF3-620 |0 G:(DE-HGF)POF3-623 |2 G:(DE-HGF)POF3-600 |v Facility topic: Neutrons for Research on Condensed Matter |9 G:(DE-HGF)POF3-6G4 |x 1 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF3 |
| 914 | 1 | _ | |y 2016 |
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