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@ARTICLE{Luchini:281845,
      author       = {Luchini, Alessandra and Irace, Carlo and Santamaria, Rita
                      and Montesarchio, Daniela and Heenan, Richard K. and
                      Szekely, Noemi and Flori, Alessandra and Menichetti, Luca
                      and Paduano, Luigi},
      title        = {{P}hosphocholine-decorated superparamagnetic iron oxide
                      nanoparticles: defining the structure and probing in vivo
                      applications},
      journal      = {Nanoscale},
      volume       = {8},
      number       = {19},
      issn         = {2040-3372},
      address      = {Cambridge},
      publisher    = {RSC Publ.},
      reportid     = {FZJ-2016-01512},
      pages        = {10078-10086},
      year         = {2016},
      abstract     = {Superparamagnetic Iron Oxide Nanoparticles (SPIONs) are
                      performing contrast agents for Magnetic Resonance Imaging
                      (MRI). A functionalization strategy for SPIONs based on
                      hydrophobic interactions is a versatile approach easily
                      extendable to several kinds of inorganic nanoparticles and
                      suitable for obtaining stable and biocompatible systems.
                      Here we report on the original preparation of functionalized
                      SPIONs with an 8 nm radius exploiting the hydrophobic
                      interaction between a phosphocholine and an inner
                      amphiphilic. With respect to other similarly functionalized
                      SPIONs, characterized by the typical nanoparticle clustering
                      that leads to large aggregates, our phosphocholine-decorated
                      SPIONs are demonstrated to be monodisperse. We report the in
                      vitro and in vivo study that proves the effective
                      applicability of phosphocholine-decorated SPIONs as MRI
                      contrast agents. The versatility of this functionalization
                      approach is highlighted by introducing on the SPION surface
                      a ruthenium-based potential antitumoral drug, named
                      ToThyCholRu. Even if in this case we observed the formation
                      of SPION clusters, ascribable to the presence of the
                      amphiphilic ruthenium complex, interesting and promising
                      antiproliferative activity points at the
                      ToThyCholRu-decorated SPIONs as potential theranostic
                      agents.},
      cin          = {JCNS (München) ; Jülich Centre for Neutron Science JCNS
                      (München) ; JCNS-FRM-II / Neutronenstreuung ; JCNS-1},
      ddc          = {600},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106},
      pnm          = {6G15 - FRM II / MLZ (POF3-6G15) / 6G4 - Jülich Centre for
                      Neutron Research (JCNS) (POF3-623)},
      pid          = {G:(DE-HGF)POF3-6G15 / G:(DE-HGF)POF3-6G4},
      experiment   = {EXP:(DE-MLZ)KWS2-20140101},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000376047200020},
      doi          = {10.1039/C5NR08486E},
      url          = {https://juser.fz-juelich.de/record/281845},
}