000281953 001__ 281953
000281953 005__ 20240619091204.0
000281953 0247_ $$2doi$$a10.1021/acsnano.5b07136
000281953 0247_ $$2ISSN$$a1936-0851
000281953 0247_ $$2ISSN$$a1936-086X
000281953 0247_ $$2WOS$$aWOS:000370987400076
000281953 0247_ $$2altmetric$$aaltmetric:5637080
000281953 0247_ $$2pmid$$apmid:26859618
000281953 037__ $$aFZJ-2016-01597
000281953 082__ $$a540
000281953 1001_ $$0P:(DE-Juel1)136674$$aTran, Duy P.$$b0
000281953 245__ $$aTowards Intraoperative Detection of Disseminated Tumor Cells in Lymph Nodes with Silicon Nanowire Field Effect Transistors
000281953 260__ $$aWashington, DC$$bSoc.$$c2016
000281953 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1456818622_17458
000281953 3367_ $$2DataCite$$aOutput Types/Journal article
000281953 3367_ $$00$$2EndNote$$aJournal Article
000281953 3367_ $$2BibTeX$$aARTICLE
000281953 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000281953 3367_ $$2DRIVER$$aarticle
000281953 520__ $$aWithin an hour, as little as one disseminated tumor cell (DTC) per lymph node can be quantitatively detected using an intraoperative biosensing platform based on silicon nanowire field-effect transistors (SiNW FET). It is also demonstrated that the integrated biosensing platform is able to detect the presence of circulating tumor cells (CTCs) in the blood of colorectal cancer patients. The presence of DTCs in lymph nodes and CTCs in peripheral blood is highly significant as it is strongly associated with poor patient prognosis. The SiNW FET sensing platform out-performed in both sensitivity and rapidity not only the current standard method based on pathological examination of tissue sections but also the emerging clinical gold standard based on molecular assays. The possibility to achieve accurate and highly sensitive analysis of the presence of DTCs in the lymphatics within the surgery time frame has the potential to spare cancer patients from an unnecessary secondary surgery, leading to reduced patient morbidity, improving their psychological wellbeing and reducing time spent in hospital. This study demonstrates the potential of nanoscale field-effect technology in clinical cancer diagnostics.
000281953 536__ $$0G:(DE-HGF)POF3-523$$a523 - Controlling Configuration-Based Phenomena (POF3-523)$$cPOF3-523$$fPOF III$$x0
000281953 588__ $$aDataset connected to CrossRef
000281953 7001_ $$0P:(DE-HGF)0$$aWinter, Marnie A.$$b1
000281953 7001_ $$0P:(DE-Juel1)128745$$aWolfrum, Bernhard$$b2
000281953 7001_ $$0P:(DE-Juel1)128733$$aStockmann, Regina$$b3
000281953 7001_ $$0P:(DE-HGF)0$$aYang, Chih-Tsung$$b4
000281953 7001_ $$0P:(DE-HGF)0$$aP. Moghaddam, Mohammad$$b5
000281953 7001_ $$0P:(DE-Juel1)128713$$aOffenhäusser, Andreas$$b6$$eCorresponding author
000281953 7001_ $$0P:(DE-HGF)0$$aThierry, Benjamin$$b7$$eCorresponding author
000281953 773__ $$0PERI:(DE-600)2383064-5$$a10.1021/acsnano.5b07136$$gp. acsnano.5b07136$$n2$$p2357–2364$$tACS nano$$v10$$x1936-086X$$y2016
000281953 8564_ $$uhttps://juser.fz-juelich.de/record/281953/files/acsnano.5b07136.pdf$$yRestricted
000281953 8564_ $$uhttps://juser.fz-juelich.de/record/281953/files/acsnano.5b07136.gif?subformat=icon$$xicon$$yRestricted
000281953 8564_ $$uhttps://juser.fz-juelich.de/record/281953/files/acsnano.5b07136.jpg?subformat=icon-1440$$xicon-1440$$yRestricted
000281953 8564_ $$uhttps://juser.fz-juelich.de/record/281953/files/acsnano.5b07136.jpg?subformat=icon-180$$xicon-180$$yRestricted
000281953 8564_ $$uhttps://juser.fz-juelich.de/record/281953/files/acsnano.5b07136.jpg?subformat=icon-640$$xicon-640$$yRestricted
000281953 8564_ $$uhttps://juser.fz-juelich.de/record/281953/files/acsnano.5b07136.pdf?subformat=pdfa$$xpdfa$$yRestricted
000281953 909CO $$ooai:juser.fz-juelich.de:281953$$pVDB
000281953 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)128745$$aForschungszentrum Jülich GmbH$$b2$$kFZJ
000281953 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)128733$$aForschungszentrum Jülich GmbH$$b3$$kFZJ
000281953 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)128713$$aForschungszentrum Jülich GmbH$$b6$$kFZJ
000281953 9131_ $$0G:(DE-HGF)POF3-523$$1G:(DE-HGF)POF3-520$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lFuture Information Technology - Fundamentals, Novel Concepts and Energy Efficiency (FIT)$$vControlling Configuration-Based Phenomena$$x0
000281953 9141_ $$y2016
000281953 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000281953 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bACS NANO : 2014
000281953 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bACS NANO : 2014
000281953 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000281953 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000281953 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000281953 915__ $$0StatID:(DE-HGF)1150$$2StatID$$aDBCoverage$$bCurrent Contents - Physical, Chemical and Earth Sciences
000281953 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000281953 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000281953 915__ $$0StatID:(DE-HGF)0550$$2StatID$$aNo Authors Fulltext
000281953 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bThomson Reuters Master Journal List
000281953 920__ $$lyes
000281953 9201_ $$0I:(DE-Juel1)ICS-8-20110106$$kICS-8$$lBioelektronik$$x0
000281953 9201_ $$0I:(DE-Juel1)PGI-8-20110106$$kPGI-8$$lBioelektronik$$x1
000281953 9201_ $$0I:(DE-82)080009_20140620$$kJARA-FIT$$lJARA-FIT$$x2
000281953 980__ $$ajournal
000281953 980__ $$aVDB
000281953 980__ $$aUNRESTRICTED
000281953 980__ $$aI:(DE-Juel1)ICS-8-20110106
000281953 980__ $$aI:(DE-Juel1)PGI-8-20110106
000281953 980__ $$aI:(DE-82)080009_20140620
000281953 981__ $$aI:(DE-Juel1)IBI-3-20200312
000281953 981__ $$aI:(DE-Juel1)PGI-8-20110106