TY  - JOUR
AU  - Tran, Duy P.
AU  - Winter, Marnie A.
AU  - Wolfrum, Bernhard
AU  - Stockmann, Regina
AU  - Yang, Chih-Tsung
AU  - P. Moghaddam, Mohammad
AU  - Offenhäusser, Andreas
AU  - Thierry, Benjamin
TI  - Towards Intraoperative Detection of Disseminated Tumor Cells in Lymph Nodes with Silicon Nanowire Field Effect Transistors
JO  - ACS nano
VL  - 10
IS  - 2
SN  - 1936-086X
CY  - Washington, DC
PB  - Soc.
M1  - FZJ-2016-01597
SP  - 2357–2364
PY  - 2016
AB  - Within an hour, as little as one disseminated tumor cell (DTC) per lymph node can be quantitatively detected using an intraoperative biosensing platform based on silicon nanowire field-effect transistors (SiNW FET). It is also demonstrated that the integrated biosensing platform is able to detect the presence of circulating tumor cells (CTCs) in the blood of colorectal cancer patients. The presence of DTCs in lymph nodes and CTCs in peripheral blood is highly significant as it is strongly associated with poor patient prognosis. The SiNW FET sensing platform out-performed in both sensitivity and rapidity not only the current standard method based on pathological examination of tissue sections but also the emerging clinical gold standard based on molecular assays. The possibility to achieve accurate and highly sensitive analysis of the presence of DTCs in the lymphatics within the surgery time frame has the potential to spare cancer patients from an unnecessary secondary surgery, leading to reduced patient morbidity, improving their psychological wellbeing and reducing time spent in hospital. This study demonstrates the potential of nanoscale field-effect technology in clinical cancer diagnostics.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000370987400076
C6  - pmid:26859618
DO  - DOI:10.1021/acsnano.5b07136
UR  - https://juser.fz-juelich.de/record/281953
ER  -