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@ARTICLE{Tran:281953,
      author       = {Tran, Duy P. and Winter, Marnie A. and Wolfrum, Bernhard
                      and Stockmann, Regina and Yang, Chih-Tsung and P. Moghaddam,
                      Mohammad and Offenhäusser, Andreas and Thierry, Benjamin},
      title        = {{T}owards {I}ntraoperative {D}etection of {D}isseminated
                      {T}umor {C}ells in {L}ymph {N}odes with {S}ilicon {N}anowire
                      {F}ield {E}ffect {T}ransistors},
      journal      = {ACS nano},
      volume       = {10},
      number       = {2},
      issn         = {1936-086X},
      address      = {Washington, DC},
      publisher    = {Soc.},
      reportid     = {FZJ-2016-01597},
      pages        = {2357–2364},
      year         = {2016},
      abstract     = {Within an hour, as little as one disseminated tumor cell
                      (DTC) per lymph node can be quantitatively detected using an
                      intraoperative biosensing platform based on silicon nanowire
                      field-effect transistors (SiNW FET). It is also demonstrated
                      that the integrated biosensing platform is able to detect
                      the presence of circulating tumor cells (CTCs) in the blood
                      of colorectal cancer patients. The presence of DTCs in lymph
                      nodes and CTCs in peripheral blood is highly significant as
                      it is strongly associated with poor patient prognosis. The
                      SiNW FET sensing platform out-performed in both sensitivity
                      and rapidity not only the current standard method based on
                      pathological examination of tissue sections but also the
                      emerging clinical gold standard based on molecular assays.
                      The possibility to achieve accurate and highly sensitive
                      analysis of the presence of DTCs in the lymphatics within
                      the surgery time frame has the potential to spare cancer
                      patients from an unnecessary secondary surgery, leading to
                      reduced patient morbidity, improving their psychological
                      wellbeing and reducing time spent in hospital. This study
                      demonstrates the potential of nanoscale field-effect
                      technology in clinical cancer diagnostics.},
      cin          = {ICS-8 / PGI-8 / JARA-FIT},
      ddc          = {540},
      cid          = {I:(DE-Juel1)ICS-8-20110106 / I:(DE-Juel1)PGI-8-20110106 /
                      $I:(DE-82)080009_20140620$},
      pnm          = {523 - Controlling Configuration-Based Phenomena (POF3-523)},
      pid          = {G:(DE-HGF)POF3-523},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000370987400076},
      pubmed       = {pmid:26859618},
      doi          = {10.1021/acsnano.5b07136},
      url          = {https://juser.fz-juelich.de/record/281953},
}