%0 Journal Article
%A Krämer, Christina
%A Kohlheyer, Dietrich
%T Mikrobiologische Einzelzell-Phänotypencharakterisierung im Mikrochip
%J Biospektrum
%V 22
%N 1
%@ 1868-6249
%C Heidelberg
%I Spektrum
%M FZJ-2016-01660
%P 48 - 50
%D 2016
%X Microbes adapt to environmental changes by DNA embedded mechanisms (e. g. resistance) or non-DNA based phenotypical differentiation (e. g. tolerance). Single-cell fluorescence imaging combined with environmental control by microfluidic devices helps to unravel phenotypical changes of single microbial cells in isogenic cell populations. Therefore, the intracellular implementation of fluorescent molecules by genetic modification or dynamic staining is essential for non-invasive live-cell imaging.
%F PUB:(DE-HGF)16
%9 Journal Article
%R 10.1007/s12268-016-0658-3
%U https://juser.fz-juelich.de/record/282926